Publicação
A molecular perspective on colistin and Klebsiella pneumoniae: mode of action, resistance genetics, and phenotypic susceptibility
| datacite.subject.fos | Ciências Médicas | |
| datacite.subject.sdg | 03:Saúde de Qualidade | |
| dc.contributor.author | Elias, Rita | |
| dc.contributor.author | Duarte, Aida | |
| dc.contributor.author | Perdigão, João | |
| dc.date.accessioned | 2025-09-08T09:28:13Z | |
| dc.date.available | 2025-09-08T09:28:13Z | |
| dc.date.issued | 2021-07 | |
| dc.description.abstract | Klebsiella pneumoniae is a rod-shaped, encapsulated, Gram-negative bacteria associated with multiple nosocomial infections. Multidrug-resistant (MDR) K. pneumoniae strains have been increasing and the therapeutic options are increasingly limited. Colistin is a long-used, polycationic, heptapeptide that has regained attention due to its activity against Gram-negative bacteria, including the MDR K. pneumoniae strains. However, this antibiotic has a complex mode of action that is still under research along with numerous side-effects. The acquisition of colistin resistance is mainly associated with alteration of lipid A net charge through the addition of cationic groups synthesized by the gene products of a multi-genic regulatory network. Besides mutations in these chromosomal genes, colistin resistance can also be achieved through the acquisition of plasmid-encoded genes. Nevertheless, the diversity of molecular markers for colistin resistance along with some adverse colistin properties compromises the reliability of colistin-resistance monitorization methods. The present review is focused on the colistin action and molecular resistance mechanisms, along with specific limitations on drug susceptibility testing for K. pneumoniae. | eng |
| dc.identifier.citation | Elias R, Duarte A, Perdigão J. A Molecular Perspective on Colistin and Klebsiella pneumoniae: Mode of Action, Resistance Genetics, and Phenotypic Susceptibility. Diagnostics. 2021; 11(7):1165. https://doi.org/10.3390/diagnostics11071165 | |
| dc.identifier.doi | 10.3390/diagnostics11071165 | |
| dc.identifier.issn | 2075-4418 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/58596 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | MDPI | |
| dc.relation.hasversion | https://doi.org/10.3390/diagnostics11071165 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Klebsiella pneumoniae | |
| dc.subject | colistin | |
| dc.subject | lipid A | |
| dc.subject | resistance mechanisms | |
| dc.subject | susceptibility testing | |
| dc.title | A molecular perspective on colistin and Klebsiella pneumoniae: mode of action, resistance genetics, and phenotypic susceptibility | eng |
| dc.type | contribution to journal | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 7 | |
| oaire.citation.startPage | 1165 | |
| oaire.citation.title | Diagnostics | |
| oaire.citation.volume | 11 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |