Logo do repositório
 
Publicação

Analysis of drugs of abuse and contaminants in individuals under drug surveillance programs: A study in hair samples.

2025-06Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorSimão, A Y
dc.contributor.authorTokuyama, P Y
dc.contributor.authorZampieri, G
dc.contributor.authorRocha, V
dc.contributor.authorMadruga, C
dc.contributor.authorIsicawa, K
dc.contributor.authorCidade, L S
dc.contributor.authorAlmeida, K R
dc.contributor.authorda Silva, N R
dc.contributor.authorBarroso, Mário
dc.contributor.authorAndraus, M
dc.contributor.authorGallardo, E
dc.date.accessioned2026-01-29T16:06:48Z
dc.date.available2026-01-29T16:06:48Z
dc.date.issued2025-06
dc.description.abstractIn this study, over 900 hair samples from individuals using drugs of abuse in São Paulo and Rio Grande do Sul, Brazil were analysed for classical drugs and new psychoactive substances (NPS) in hair samples. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods were developed for the detection of some drugs (25B-NBOMe, 25C-NBOMe, 25E-NBOH, 2C-C, 2C-I, 3,4-MDPHP, 3-MeO-PCP, 5F-MDMB-PINACA, 5-MeO-DMT, cannabidiol, ethylone, JWH 073, ketamine, mephedrone and UR-144) and drug adulterants (levamisole, phenacetin, strychnine); other substances including cocaine, amphetamines, benzodiazepines, opioids, cannabinoids were also analysed. The methods demonstrated good selectivity, linearity with lower limits of quantification ranging from 0.02 to 0.26 ng/mg, as well as precision and accuracy meeting ISO/IEC 17025 criteria. A total of 29.8 % samples were positive for at least one drug. Cocaine and its metabolites were the most frequently detected, with benzoylecgonine (111 cases), cocaine (88 cases), and cocaethylene (37 cases), highlighting prevalent cocaine use. Cannabinoids were also common, with THC (57 cases) and CBN (48 cases) detected. The presence of adulterants such as phenacetin (76 cases), levamisole (14 cases), and strychnine (3 cases) were also identified. Additionally, 5F-MDMB-PINACA was also detected (5 cases), along with ketamine (9 cases). Findings also highlighted a prevalence of poly-drug consumption, where THC was frequently detected with cocaine (20 cases) and benzoylecgonine (26 cases). CBN also showed notable associations with cocaine (16 cases) and benzoylecgonine (22 cases). These findings provide important insights into the evolving drug landscape in Brazil and highlight the effectiveness of hair analysis as a tool for monitoring drug use.eng
dc.identifier.citationSimão, A. Y., Tokuyama, P. Y., Zampieri, G., Rocha, V., Madruga, C., Isicawa, K., Cidade, L. S., Almeida, K. R., da Silva, N. R., Barroso, M., Andraus, M., & Gallardo, E. (2025). Analysis of drugs of abuse and contaminants in individuals under drug surveillance programs: A study in hair samples. Forensic science international, 371, 112493.
dc.identifier.doi10.1016/j.forsciint.2025.112493
dc.identifier.issn1872-6283
dc.identifier.urihttp://hdl.handle.net/10400.26/61310
dc.language.isoen
dc.peerreviewedyes
dc.publisherElsevier
dc.relationHealth Sciences Research Centre
dc.relationHealth Sciences Research Centre
dc.relationhttps://doi.org/10.54499/2020.09070.BD
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCocaine contaminants
dc.subjectDrugs of abuse
dc.subjectHair analysis
dc.subjectLC-MS/MS
dc.subjectPsychoactive substances
dc.titleAnalysis of drugs of abuse and contaminants in individuals under drug surveillance programs: A study in hair samples.eng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleHealth Sciences Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00709%2F2020/PT
oaire.citation.titleForensic science international
oaire.citation.volume371
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameBarroso
person.givenNameMário
person.identifier.ciencia-id5110-F476-ECCC
person.identifier.orcid0000-0001-8848-2734
person.identifier.scopus-author-id35329243100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublication294b555e-48c4-4013-b981-b8917400c56c
relation.isAuthorOfPublication.latestForDiscovery294b555e-48c4-4013-b981-b8917400c56c
relation.isProjectOfPublication4ca3c3c9-1802-4c7f-8730-9547236896fe
relation.isProjectOfPublication56ce2e5c-35e5-4eb7-8152-2e87e77f638c
relation.isProjectOfPublication.latestForDiscovery4ca3c3c9-1802-4c7f-8730-9547236896fe

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
Analysis of drugs of abuse and contaminants in individual.pdf
Tamanho:
480.08 KB
Formato:
Adobe Portable Document Format
Ver/Abrir
Licença
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
license.txt
Tamanho:
1.85 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Ver/Abrir

Coleções

INMLCF - Artigos Científicos