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Publication
A inter-relação entre as doenças hepáticas e a cavidade oral
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Abstract(s)
O fígado é um órgão de importância vital e qualquer disfunção terá consequências graves para o nosso corpo em geral. A cirrose, a patologia crónica mais frequente do fígado, constitui um grande problema de saúde pública.
A cirrose hepática é uma doença crónica que se desenvolve devido à destruição de células hepáticas, bem como sua regeneração de forma desordenada. É uma doença que ocorre na fase final das doenças hepáticas crónicas com uma perturbação irreversível da sua estrutura e função normais.
Dependendo da sua etiologia e gravidade, a doença apresenta diferentes sintomas e complicações, bem como manifestações orais com a influência de bactérias. Estas bactérias desempenham um papel importante no aparecimento da periodontite, bem como no desenvolvimento de doenças crónicas do fígado, principalmente da esteatose hepática não alcoólica.
O microbioma intestinal e a doença hepática comunicam através da veia porta. Portanto, na doença hepática, a disbiose intestinal é formada com a presença de bactérias orais. Por outro lado, a inflamação crónica associada à periodontite parece contribuir para a fisiopatologia e progressão natural da doença hepática crónica.
Assim parece existir uma certa relação bidirecional, razão pela qual está a emergir um novo eixo oral-intestinal-fígado. No entanto, esta associação ainda não está totalmente estabelecida.
The liver is a vitally important organ and any dysfunction will have serious consequences for our body in general. Cirrhosis, the most common chronic liver disease, is a major public health problem. Liver cirrhosis is a chronic disease that develops as a result of the destruction of liver cells as well as their regeneration in a disordered way. It is a disease that occurs in the final phase of chronic liver diseases with an irreversible disruption of its normal structure and function. Depending on its aetiology and severity, the disease presents different symptoms and complications, as well as oral manifestations with the influence of bacteria. These bacteria play an important role in the onset of periodontitis as well as in the development of chronic liver diseases, especially non-alcoholic fatty liver disease. The gut microbiome and liver disease communicate through the portal vein. Therefore, in liver disease, gut dysbiosis is formed with the presence of oral bacteria. Also, the chronic inflammation associated with periodontitis appears to contribute to the pathophysiology and natural progression of chronic liver diseases. Thus, there seems to be a certain bidirectional relationship, which is why a new oral-intestinal-liver axis is emerging. However, this association is not yet fully established.
The liver is a vitally important organ and any dysfunction will have serious consequences for our body in general. Cirrhosis, the most common chronic liver disease, is a major public health problem. Liver cirrhosis is a chronic disease that develops as a result of the destruction of liver cells as well as their regeneration in a disordered way. It is a disease that occurs in the final phase of chronic liver diseases with an irreversible disruption of its normal structure and function. Depending on its aetiology and severity, the disease presents different symptoms and complications, as well as oral manifestations with the influence of bacteria. These bacteria play an important role in the onset of periodontitis as well as in the development of chronic liver diseases, especially non-alcoholic fatty liver disease. The gut microbiome and liver disease communicate through the portal vein. Therefore, in liver disease, gut dysbiosis is formed with the presence of oral bacteria. Also, the chronic inflammation associated with periodontitis appears to contribute to the pathophysiology and natural progression of chronic liver diseases. Thus, there seems to be a certain bidirectional relationship, which is why a new oral-intestinal-liver axis is emerging. However, this association is not yet fully established.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Doenças hepáticas Cirrose hepática Manifestações orais Microbiota