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Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal

dc.contributor.authorBorges, Vítor
dc.contributor.authorDuque, Mariana Perez
dc.contributor.authorMartins, João Vieira
dc.contributor.authorVasconcelos, Paula
dc.contributor.authorFerreira, Rita
dc.contributor.authorSobral, Daniel
dc.contributor.authorPelerito, Ana
dc.contributor.authorde Carvalho, Isabel Lopes
dc.contributor.authorNúncio, Maria Sofia
dc.contributor.authorBorrego, Maria José
dc.contributor.authorRoemer, Cornelius
dc.contributor.authorNeher, Richard A.
dc.contributor.authorO’Driscoll, Megan
dc.contributor.authorRocha, Raquel
dc.contributor.authorLopo, Sílvia
dc.contributor.authorNeves, Raquel
dc.contributor.authorPalminha, Paula
dc.contributor.authorCoelho, Luís
dc.contributor.authorNunes, Alexandra
dc.contributor.authorIsidro, Joana
dc.contributor.authorPinto, Miguel
dc.contributor.authorSantos, João Dourado
dc.contributor.authorMixão, Verónica
dc.contributor.authorSantos, Daniela
dc.contributor.authorDuarte, Silvia
dc.contributor.authorVieira, Luís
dc.contributor.authorMartins, Fátima
dc.contributor.authorMachado, Jorge
dc.contributor.authorVeríssimo, Vítor Cabral
dc.contributor.authorGrau, Berta
dc.contributor.authorPeralta-Santos, André
dc.contributor.authorNeves, José
dc.contributor.authorCaldeira, Margarida
dc.contributor.authorPestana, Mafalda
dc.contributor.authorFernandes, Cândida
dc.contributor.authorCaria, João
dc.contributor.authorPinto, Raquel
dc.contributor.authorPóvoas, Diana
dc.contributor.authorMaltez, Fernando
dc.contributor.authorSá, Ana Isabel
dc.contributor.authorSalvador, Mafalda Brito
dc.contributor.authorTeófilo, Eugénio
dc.contributor.authorRocha, Miguel
dc.contributor.authorMoneti, Virginia
dc.contributor.authorDuque, Luis Miguel
dc.contributor.authore Silva, Francisco Ferreira
dc.contributor.authorBaptista, Teresa
dc.contributor.authorVasconcelos, Joana
dc.contributor.authorCasanova, Sara
dc.contributor.authorMansinho, Kamal
dc.contributor.authorAlves, João Vaz
dc.contributor.authorAlves, João
dc.contributor.authorSilva, António
dc.contributor.authorAlpalhão, Miguel
dc.contributor.authorBrazão, Cláudia
dc.contributor.authorSousa, Diogo
dc.contributor.authorFilipe, Paulo
dc.contributor.authorPacheco, Patrícia
dc.contributor.authorPeruzzu, Francesca
dc.contributor.authorde Jesus, Rita Patrocínio
dc.contributor.authorFerreira, Luís
dc.contributor.authorMendez, Josefina
dc.contributor.authorJordão, Sofia
dc.contributor.authorDuarte, Frederico
dc.contributor.authorGonçalves, Maria João
dc.contributor.authorPena, Eduarda
dc.contributor.authorSilva, Claúdio Nunes
dc.contributor.authorGuimarães, André Rodrigues
dc.contributor.authorTavares, Margarida
dc.contributor.authorFreitas, Graça
dc.contributor.authorCordeiro, Rita
dc.contributor.authorGomes, João Paulo
dc.date.accessioned2024-04-23T13:50:48Z
dc.date.available2024-04-23T13:50:48Z
dc.date.issued2023-09-11
dc.description.abstractPathogen genome sequencing during epidemics enhances our ability to identify and understand suspected clusters and investigate their relationships. Here, we combine genomic and epidemiological data of the 2022 mpox outbreak to better understand early viral spread, diversification and transmission dynamics. By sequencing 52% of the confirmed cases in Portugal, we identified the mpox virus sublineages with the highest impact on case numbers and fitted them into a global context, finding evidence that several international sublineages probably emerged or spread early in Portugal. We estimated a 62% infection reporting rate and that 1.3% of the population of men who have sex with men in Portugal were infected. We infer the critical role played by sexual networks and superspreader gatherings, such as sauna attendance, in the dissemination of mpox virus. Overall, our findings highlight genomic epidemiology as a tool for the real-time monitoring and control of mpox epidemics, and can guide future vaccine policy in a highly susceptible population.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1038/s41591-023-02542-xpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/50710
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationHERA (Human and Environmental Risk Assessment) project (Grant/2021/PHF/23776)pt_PT
dc.relationGenomePT project (POCI-01-0145-FEDER-022184)pt_PT
dc.relationERINHA-Advance project (funded by the European Union’s Horizon 2020 Research & Innovation program, grant agreement no. 824061)pt_PT
dc.relationPromoting One Health in Europe through joint actions on foodborne zoonoses, antimicrobial resistance and emerging microbiological hazards.
dc.relationGates Cambridge Scholarship (no. OPP1144)pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMPOXpt_PT
dc.subjectPortugalpt_PT
dc.subjectMen who have sex with menpt_PT
dc.subjectGenomic epidemiologypt_PT
dc.titleViral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePromoting One Health in Europe through joint actions on foodborne zoonoses, antimicrobial resistance and emerging microbiological hazards.
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/773830/EU
oaire.citation.endPage2517pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage2509pt_PT
oaire.citation.titleNature Medicinept_PT
oaire.citation.volume29pt_PT
oaire.fundingStreamH2020
person.familyNameRocha
person.familyNameBaptista
person.givenNameMiguel
person.givenNameTeresa
person.identifier999820
person.identifier.ciencia-id5F19-66C4-5F80
person.identifier.orcid0000-0003-1057-2419
person.identifier.orcid0009-0006-6191-6428
person.identifier.ridAAL-7984-2020
person.identifier.scopus-author-id57204739884
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationf47c1e01-1192-4946-89a8-66594bb7364e
relation.isAuthorOfPublication36e580a7-297a-4a13-ae8f-3c419c4bca5b
relation.isAuthorOfPublication.latestForDiscoveryf47c1e01-1192-4946-89a8-66594bb7364e
relation.isProjectOfPublicationfdd51bee-bdef-41a4-ae6c-394f1ea93fdb
relation.isProjectOfPublication.latestForDiscoveryfdd51bee-bdef-41a4-ae6c-394f1ea93fdb

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