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High-intensity infrasound effects on glucose metabolism in rats

2021-08Contribution to journal Open access
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datacite.subject.fosCiências Médicas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorPereira, Gonçalo Martins
dc.contributor.authorSantos, Madalena
dc.contributor.authorPereira, Sofia S.
dc.contributor.authorBorrecho, Gonçalo
dc.contributor.authorTortosa, Francisco
dc.contributor.authorBrito, José
dc.contributor.authorFreitas, Diamantino
dc.contributor.authorCarvalho, António Oliveira de
dc.contributor.authorÁguas, Artur
dc.contributor.authorOliveira, Maria João
dc.contributor.authorOliveira, Pedro
dc.date.accessioned2025-09-19T11:02:32Z
dc.date.available2025-09-19T11:02:32Z
dc.date.issued2021-08
dc.description.abstractRecent focus has been given on the effects of high-intensity infrasound (HII) exposure, and whether it induces changes in pancreatic morphology and glucose metabolism is still unknown. As such, we have studied the impact of HII exposure on glucose tolerance, insulin sensitivity, pancreatic islet morphology, muscle GLUT4 and plasma insulin and corticosterone levels. Normal and glucose intolerant wild-type Wistar rats were randomly divided in two groups: one group not exposed to HII and the other continuously exposed to HII. Animals were sacrificed at three timepoints of exposure (1, 6 or 12 weeks). An intraperitoneal glucose tolerance test was performed, blood samples were collected and the pancreas and the quadriceps femoris muscle were excised. Circulating insulin and corticosterone levels were determined and pancreatic and muscular tissue were routinely processed for histochemistry and immunohistochemistry with an anti-GLUT4 antibody. Animals exposed to HII had higher corticosterone levels than animals not exposed. No differences were found on insulin concerning HII exposure or glucose intolerance. Glucose intolerant animals had pancreatic islet fibrosis and no differences were found in GLUT4 ratio concerning HII exposure. In conclusion, we found that continuous exposure to HII increases stress hormone levels without inducing glucose intolerance in rats.eng
dc.identifier.citationPereira, G.M., Santos, M., Pereira, S.S. et al. High-intensity infrasound effects on glucose metabolism in rats. Sci Rep 11, 17273 (2021). https://doi.org/10.1038/s41598-021-96796-5
dc.identifier.doi10.1038/s41598-021-96796-5
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10400.26/58740
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer Nature
dc.relation.hasversionhttps://doi.org/10.1038/s41598-021-96796-5
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAnimal disease models
dc.subjectEndocrine system and metabolic diseases
dc.subjectPathogenesis
dc.titleHigh-intensity infrasound effects on glucose metabolism in ratseng
dc.typecontribution to journal
dspace.entity.typePublication
oaire.citation.startPage17273
oaire.citation.titleScientific Reports
oaire.citation.volume11
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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