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MDMA Intoxication in potential donor with cardiac arrest – A case report

2019-09-02Conference object Open access
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dc.contributor.authorCastro, André Lobo
dc.contributor.authorTarelho, Sónia
dc.contributor.authorAlmeida, Dina
dc.contributor.authorSousa, Lara
dc.contributor.authorFranco, João Miguel
dc.contributor.authorTeixeira, Helena
dc.date.accessioned2023-09-05T09:50:43Z
dc.date.available2023-09-05T09:50:43Z
dc.date.issued2019-09-02
dc.descriptionPoster apresentado no 57th Annual Meeting of The International Association of Forensic Toxicologists, Birmingham (Reino Unido), 2019pt_PT
dc.description.abstractAmphetamines consumption is still an important public health issue, namely in terms of compounds variability and disposition to consumers. However, some of them, still classic substances, keep standing in the illicit market, with remarkable and continuous success. That is the case of MDMA. Nevertheless, there is always new information and data on MDMA intoxication, both in vivo as in post-mortem context. The authors report an intoxication case with MDMA in an 18 years old male, who was considered a potential organ donor, after a cardiac arrest. Whole blood samples were collected in vivo, at the Emergency Room (ER), in different moments, and post-mortem, at the Forensic Pathology Service of the National Institute of Legal Medicine and Forensic Science. After a general screening procedure, samples were extracted by an SPE procedure (OASIS® MCX) followed by a GC-MS single quad analysis. The post-mortem whole blood sample was positive for Lidocaine (< 500 ng/mL), compatible with ER intervention, and positive for MDMA (2278 ng/mL) and MDA (49 ng/mL), while the whole blood samples collected in vivo (during the maintenance of the individual under advanced life support), were positive for MDMA (between 504 ng/mL and 1918 ng/mL) and MDA (between 20 ng/mL and 89 ng/mL). The samples were negative for other substances, namely ethanol, other drugs of abuse and medicines. Interpretation of these results is pivotal to understand the behaviour of the substance. So, in this case, MDMA post-mortem behaviour should be carefully evaluated, considering as possible influencers, in the specific context of the case, the time lapse between the death verification, the maintenance of the advanced life support and the body manipulation for organ collection purposes. Also referred and discussed is the ante-mortem/post-mortem ratio of MDMA obtained values, compared with literature references. No doubt that death was due to MDMA intoxication, but information from the in vivo samples analysis suggests that this type of sample should also be considered, in a complementary role, whenever possible.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/46384
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectMDMA Intoxicationpt_PT
dc.subjectOrgan donorpt_PT
dc.titleMDMA Intoxication in potential donor with cardiac arrest – A case reportpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceBirmingham, Reino Unidopt_PT
oaire.citation.title57th Annual Meeting of The International Association of Forensic Toxicologistspt_PT
person.familyNameLobo Castro
person.familyNameTarelho
person.familyNamede Almeida
person.familyNameFranco
person.familyNameTeixeira
person.givenNameAndré
person.givenNameSónia
person.givenNameDina Filipa
person.givenNameJoão
person.givenNameHelena M.
person.identifier.ciencia-id4C18-E51A-01E2
person.identifier.ciencia-id4214-85EB-E58C
person.identifier.orcid0000-0002-7258-8523
person.identifier.orcid0000-0001-8366-6702
person.identifier.orcid0000-0002-3143-5758
person.identifier.orcid0000-0002-3268-3841
person.identifier.orcid0000-0001-7570-5521
person.identifier.scopus-author-id7003981256
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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relation.isAuthorOfPublication631cbcb7-4c75-4fc1-b4cf-8445d428f1de
relation.isAuthorOfPublicatione0386f23-de82-4c77-a978-6bbdb15005d7
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relation.isAuthorOfPublication04b8f471-69fa-4cc1-942a-7bc7e690a0d4
relation.isAuthorOfPublication.latestForDiscovery045c4125-1313-445f-b05f-b7f204886052

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