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Clinical diagnostic criteria have a high impact on the frequency of dementia in late-stage Parkinson's disease

2021-05Journal article Open access
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dc.contributor.authorSousa, Catarina Severiano e
dc.contributor.authorFabbri, Margherita
dc.contributor.authorGodinho, Catarina
dc.contributor.authorSimões, Rita
dc.contributor.authorChendo, Inês
dc.contributor.authorCoelho, Miguel
dc.contributor.authorMartins, Isabel Pavão
dc.contributor.authorFerreira, Joaquim J.
dc.date.accessioned2022-04-01T15:26:04Z
dc.date.available2022-04-01T15:26:04Z
dc.date.issued2021-05
dc.descriptionThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.pt_PT
dc.description.abstractBackground: Cognitive impairment is a potential late feature of Parkinson's disease (PD). However, studies in patients with late-stage PD are lacking due to the particular characteristics of this population.pt_PT
dc.description.abstractObjectives: To evaluate the frequency of dementia in late-stage PD patients and to assess the impact of using different diagnostic criteria.pt_PT
dc.description.abstractMethods: We conducted a cross-sectional study to estimate the frequency of dementia in late-stage PD patients using the International Parkinson and Movement Disorders Society (MDS) (Level II) clinical diagnostic criteria as the primary outcome. We also applied other diagnostic criteria [MDS (Level I), DSM-IV, and DSM-5 criteria] to determine their applicability and impact on dementia frequency.pt_PT
dc.description.abstractResults: 93 participants with a mean age of 75.8 years (SD 6.8) and 16.5 years (SD 7.5) of disease duration were included. 64.3% were classified as demented using the International Parkinson and Movement Disorders Society (MDS) (Level II) clinical diagnostic criteria. We observed a high discrepancy on the frequency of dementia depending on the criteria applied [6.2% with MDS (Level I), 58.8% with DSM-IV, and 72.0% with DSM-5 criteria].pt_PT
dc.description.abstractConclusions: We found a frequency of dementia below what was observed in similar populations. The particular characteristics of our sample may have contributed as protective factors for late-stage dementia. Dementia frequency varied depending on the criteria used mainly due to the presence of major depression.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSeveriano e Sousa C, Fabbri M, Godinho C, Simões R, Chendo I, Coelho M, Martins IP and Ferreira JJ (2021) Clinical Diagnostic Criteria Have a High Impact on the Frequency of Dementia in Late-Stage Parkinson's Disease. Front. Neurol. 12:652424. doi: 10.3389/fneur.2021.652424pt_PT
dc.identifier.doi10.3389/fneur.2021.652424pt_PT
dc.identifier.issn1664-2295
dc.identifier.urihttp://hdl.handle.net/10400.26/40020
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relation.publisherversionhttps://doi.org/10.3389/fneur.2021.652424pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectParkinson's diseasept_PT
dc.subjectLate-stagept_PT
dc.subjectDementiapt_PT
dc.subjectCognitive impairmentpt_PT
dc.subjectDiagnostic criteriapt_PT
dc.titleClinical diagnostic criteria have a high impact on the frequency of dementia in late-stage Parkinson's diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage652424pt_PT
oaire.citation.titleFrontiers in neurologypt_PT
oaire.citation.volume12pt_PT
person.familyNameGodinho
person.givenNameCatarina
person.identifierABF-6650-2020
person.identifier.ciencia-id3919-33C7-AAF3
person.identifier.orcid0000-0003-2304-3129
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd399ed41-ae52-47d2-98aa-9de8dce31b05
relation.isAuthorOfPublication.latestForDiscoveryd399ed41-ae52-47d2-98aa-9de8dce31b05

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