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Genetic polymorphisms and asthma: findings from a case–control study in the Madeira island

2014Journal article Open access
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dc.contributor.authorBerenguer, Anabela Gonçalves
dc.contributor.authorOliveira, Susana
dc.contributor.authorFernandes, Ana Teresa
dc.contributor.authorRodrigues, Mariana
dc.contributor.authorOrnelas, Pedro
dc.contributor.authorOrnelas, Pedro
dc.contributor.authorRomeira, Diogo
dc.contributor.authorSerrão, Tânia
dc.contributor.authorRosa, Alexandra
dc.date.accessioned2019-09-18T15:00:34Z
dc.date.available2019-09-18T15:00:34Z
dc.date.issued2014
dc.description.abstractBackground Asthma is a complex disease influenced by multiple genetic and environmental factors. While Madeira has the highest prevalence of asthma in Portugal (14.6%), the effect of both genetic and environmental factors in this population has never been assessed. We categorized 98 asthma patients according to the Global Initiative for Asthma (GINA) guidelines, established their sensitization profile, and measured their forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) indexes. Selected single nucleotide polymorphisms (SNPs) were analysed as potential markers for asthma susceptibility and severity in the interleukin 4 (IL4), interleukin 13 (IL13), beta-2-adrenergic receptor (ADRB2), a disintegrin and metalloprotease 33 (ADAM33), gasdermin-like (GSDML) and the signal transducer and activator of transcription 6 (STAT6) genes comparatively to a population reference set.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBiological Research 2014 47:40.pt_PT
dc.identifier.doidoi:10.1186/0717-6287-47-40pt_PT
dc.identifier.issn0717-6287
dc.identifier.urihttp://hdl.handle.net/10400.26/29716
dc.language.isoengpt_PT
dc.publisherBiomedCentralpt_PT
dc.relation.publisherversionhttp://www.biolres.com/content/47/1/40pt_PT
dc.subjectGenetic polymorphismspt_PT
dc.subjectasthmapt_PT
dc.subjectMadeira Islandpt_PT
dc.titleGenetic polymorphisms and asthma: findings from a case–control study in the Madeira islandpt_PT
dc.typejournal article
dspace.entity.typePublication
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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