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Predictors of drooling severity in people with Parkinson’s disease

2025-01-15Journal article Open access
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dc.contributor.authorNascimento, David
dc.contributor.authorMeira, Bruna
dc.contributor.authorGarcez, Luís
dc.contributor.authorAbreu, Daisy
dc.contributor.authorOuteiro, Tiago
dc.contributor.authorGuimarães, Isabel
dc.contributor.authorFerreira, Joaquim J.
dc.date.accessioned2025-02-18T14:42:39Z
dc.date.available2025-02-18T14:42:39Z
dc.date.issued2025-01-15
dc.description.abstractBackground Drooling, defned as the unintentional loss of saliva from the anterior oral cavity, remains poorly understood in terms of the underlying clinical factors in people with Parkinson’s disease (PwP). This study aims to clarify these factors by analyzing predictors and secondarily the correlates with the severity of drooling in PwP. Methods We conducted a cross-sectional study involving 42 PwP with drooling and 59 without drooling. Clinical assess ments were performed, and the primary outcome was the item 2.2 Saliva and drooling of the Movement Disorder Society Unifed Parkinson’s Disease Rating Scale. The Mann–Whitney test was used to compare the distribution diferences in clinical variables between PwP with and without drooling. The Spearman test was used to examine correlations with drooling, and ordinal logistic regression was used to examine predictors of drooling. Results PwP with drooling showed signifcantly greater impairments in axial signs, posture, facial expression, speech, swallowing, oromotor, motor and non-motor domains than PwP without drooling. Longer disease duration, higher disease severity, levodopa equivalent daily dose, axial signs, unstimulated salivary fow rate, and impairments in speech, posture, facial expression, swallowing, oromotor, motor and non-motor domains were signifcantly correlated with a higher score on the item 2.2. Male sex, poorer swallowing, oromotor and speech functions were strong predictors of higher scores on the item 2.2 Saliva and drooling. Conclusions Male PwP with swallowing disorders, oromotor and speech impairments are signifcantly more likely to have severe drooling. Targeted interventions aimed at these swallowing, oromotor, and speech impairments may ofer promising approaches to reducing drooling severity in PwP.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doihttps://doi.org/10.1007/s00415-024-12739-wpt_PT
dc.identifier.issn1432-1459
dc.identifier.urihttp://hdl.handle.net/10400.26/54451
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.subjectParkinson’s diseasept_PT
dc.subjectDroolingpt_PT
dc.subjectSialorrheapt_PT
dc.subjectSaliva controlpt_PT
dc.subjectSalivationpt_PT
dc.titlePredictors of drooling severity in people with Parkinson’s diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage12pt_PT
oaire.citation.issue129pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleJournal of Neurologypt_PT
oaire.citation.volume272pt_PT
person.familyNameGuimarães
person.givenNameIsabel
person.identifier548796
person.identifier.ciencia-idF014-BFD6-49C2
person.identifier.orcid0000-0001-8524-8731
person.identifier.scopus-author-id24586862700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationdc9a77a2-eecf-4d30-88fa-4200275eccf5
relation.isAuthorOfPublication.latestForDiscoverydc9a77a2-eecf-4d30-88fa-4200275eccf5

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