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Browsing Saúde - CUF - Porto by Subject "Ácido Ascórbico"
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- A prospective study demonstrating improved visualization when capsule endoscopy is performed after preparation with polyethylene glycol and ascorbic acidPublication . Mascarenhas Saraiva, MCapsule endoscopy is used increasingly to obtain images of the gastrointestinal tract, yet it still remains unclear what is the best preparation for this type of exploration. Thus, the aim of this study was to compare the results of capsule endoscopy explorations performed after a basic preparation with a clear liquid diet, reduced iron intake and fasting or following preparation with a PEG/ascorbate solution. The results obtained from a prospective intervention group that used a PEG/ascorbate solution to prepare for capsule endoscopy were compared with those from a retrospective group of patients who followed the more basic preparation. The quality of visualization was assessed with the Park score, assessing visualization of the mucosal surface and the cleanliness of the intestinal lumen. The capsule transit time in different segments of the gastrointestinal tract was also evaluated. A significant improvement in the quality of small intestine visualization was observed in individuals prepared with the PEG/ascorbate solution as opposed to the basic preparation. Indeed, there were significant differences in the two separate components that contribute to the overall visualization score, with better mucosa visualization and lumen content scores in the intervention group, reflecting improved performance. The presence of diabetes appears to affect the results of these explorations, at least when employing the PEG/ascorbate preparation. As such, preparation with a PEG/ascorbate solution improves the results of capsule endoscopy when compared to a basic preparation, without the inconvenience of the more stringent preparations used for colonoscopies.
- The Use of a PEG/Ascorbate Booster Following Standard Bowel Preparation Improves Visualization for Capsule Endoscopy in a Randomized, Controlled StudyPublication . Mascarenhas-Saraiva, MJ; Oliveira, E; Mascarenhas-Saraiva, MNBackground/aims: The increasing use of capsule endoscopy (CE) to examine the gastrointestinal tract highlights the need to establish intestinal preparations that ensure optimal visualization while maximizing patient adherence. Thus, we assessed whether bowel preparation involving dietary restriction and a booster regimen produces adequate CE visualization in a real-world clinical setting. Methods: We conducted a randomized, double-blind, prospective study of CE procedures at 2 tertiary-care centers. Patients were allocated to 3 groups: group 1 followed a clear liquid diet and fasting-based bowel preparation for the exploration (n = 55); group 2 followed the same procedure as group 1 and then ingested 1 L of a polyethylene glycol (PEG)/ascorbic acid booster solution when the capsule reached the small intestine (n = 55); and group 3 followed the same procedure but ingesting only 0.5 L of the booster solution (n = 56). The quality of visualization and the average gastric, orocecal and small-bowel transit times were evaluated. Results: A total of 166 patients participated in the study. Significantly higher quality of visualization (Park score) was obtained in group 3 (2.28 ± 0.59) than in group 1 (1.84 ± 0.54, P < .001), while there were no significant differences in the average gastric (range: 36.58- 48.32 min, P = .277), orocecal (range: 322.58-289.45 min, P = .072), and small-bowel transit time (range: 280.71-249.95 min, P = .286) between the 3 groups. Conclusions: Following a clear liquid diet and fasting-based bowel preparation for CE exploration, administering a booster solution of PEG/ascorbic acid after the capsule had reached the small intestine improves mucosal visualization and cleansing without affecting capsule transit times.