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- Black soldier fly (Hermetia illucens) larvae oil as an alternative to poultry oil in diets for European seabass (Dicentrarchus labrax) and gilthead seabream (Sparus aurata)Publication . Acebes, Daniel; Canada, Paula; Sá, Tiago; Silva, Andreia F.; Magalhães, Sara; Murta, Daniel; Sousa, Ricardo; Valente, Luísa M. P.; Basto, AnaInsects have emerged as an alternative protein source for aquafeeds, and more recently, attention has turned into their lipidic fraction. This study evaluated the potential of black soldier fly larvae oil (BSFLO) to replace poultry oil (PO) in diets for two key Mediterranean aquaculture species: European seabass and gilthead seabream juveniles. A control diet containing 5.2% PO was formulated, along with three experimental diets in which PO was replaced by BSFLO at 33%, 66%, and 100% (1.7%, 3.4%, and 5.2% BSFLO dietary inclusion). Fish were fed to satiation for 8 weeks (gilthead seabream) and 12 weeks (European seabass) at 23.0 ± 0.7 °C and 22.8 ± 0.6 °C, respectively. All diets were well accepted by both species, with no adverse effects on feed intake. Growth performance and feed conversion ratio improved with the full replacement of PO by BSFLO, particularly in seabass. Increasing dietary levels of BSFLO led to greater lauric acid deposition in muscle, enhanced antioxidant capacity, and reduced lipid peroxidation in both species. The complete replacement of PO by BSFLO increased the muscle n-3/n-6 PUFA ratio in both seabass and seabream. Overall, BSFLO proved to be a promising lipid source in aquafeeds for seabass and seabream, with the total PO replacement by BSFLO yielding clear performance gains in seabass and contributing to a more favourable and stable muscle lipid profile (characterized by higher n-3/n-6 ratios, improved antioxidant status, and lower lipid peroxidation) which may support product quality in both species.
- Non-pharmacological interventions modulating immune response in Parkinson's disease : where do we stand for future preventive approachesPublication . Pirovano, Elenamaria; Silva, Inês P.; Camacho, Marta; Çanak, Asuman; Aktas, Busra; Crompton, David; Gökçe, Evrim; Tan, Fu-Miao; Marino, Franca; Domingos, Josefa; Almeida, Mafalda F.; Comi, Cristoforo; Dragic, Milorad; Figueira, InêsParkinson's disease (PD) imposes a growing socioeconomic burden due to its increasing prevalence and lack of a cure. Existing treatment options primarily manage motor and nonmotor symptoms but do not halt or slow disease progression, underscoring the urgent need for more effective and preventative strategies. Growing evidence suggests a strong link between immune system dysfunction, chronic inflammation, and the early pathogenesis of Parkinson's disease, often occurring years before the onset of motor symptoms, thereby indicating a critical window for early intervention. In this review, we examine current evidence on non-pharmacological approaches such as dietary changes, physical activity, and gut microbiome regulation, focusing on their potential to modulate both peripheral and central immune responses, thereby influencing the progression of PD. Besides being complementary to standard pharmacological treatments, these approaches not only reduce systemic inflammation but may also help delay, prevent, or improve clinical management of PD by targeting and modulating its immunological foundations.
