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- Evaluation of the ability of powdered milk to produce mini-tablets to deliver paracetamol in pediatricsPublication . Pinto, Joana T.; Brachkova, Mariya; Fernandes, Ana I.; Pinto, João F."This work aims to evaluate the usefulness of powdered milk as a vehicle of drugs for direct compression into mini-tablets specifically designed for the pediatric population. A 23 full factorial design was carried out to identify the effect of selected variables and their interactions (paracetamol to milk ratio, fraction of disintegrant and compression force), on selected responses (weight variation, thickness and tensile strength of minitablets and dissolution time of paracetamol) of the mini-tablets. Tablets were manufactured according to a matrix design resulting in eight combinations of four different tableting formulations compacted at two distinct forces. Each batch of tablets was evaluated for thickness (n=6), uniformity of weight (n=20), diametric crushing strength and tensile strength (σ) (n=6) and dissolution testing (n=12). A stepwise multiple linear regression was used to identify and quantify the relationships between each response and the variables studied and their interactions. Results were analyzed by ANOVA to identify the significant variables and variable interactions responsible for the effects observed.
- Oscillation Criteria for First Order Linear Difference Equations with Several Delay ArgumentsPublication . Pinelas, Sandra; Koplatadze, Roman
- Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at $\sqrt{s}=$8 TeV with the ATLAS detectorPublication . ATLAS collaboration (2827 authors); Aguilar-Saavedra, Juan Antonio; Amor Dos Santos, Susana Patricia; Anjos, Nuno; Araque, Juan Pedro; Cantrill, Robert; Carvalho, João; Castro, Nuno Filipe; Conde Muiño, Patricia; Da Cunha Sargedas De Sousa, Mario Jose; Fiolhais, Miguel; Galhardo, Bruno; Gomes, Agostinho; Gonçalo, Ricardo; Jorge, Pedro; Lopes, Lourenco; Machado Miguens, Joana; Maio, Amélia; Maneira, José; Onofre, António; Palma, Alberto; Pedro, Rute; Pina, João Antonio; Pinto, Belmiro; Santos, Helena; Saraiva, João; Silva, José; Tavares Delgado, Ademar; Veloso, Filipe; Wolters, HelmutResults of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb ${}^{-1}$ of $\sqrt{s}=8$ TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with $p_{\mathrm {T}}> 120$ GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between $E_{\mathrm {T}}^{\mathrm {miss}}>150$ GeV and $E_{\mathrm {T}}^{\mathrm {miss}}> 700$ GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presented.
- Distributions of Topological Observables in Inclusive Three- and Four-Jet Events in pp Collisions at sqrt(s) = 7 TeVPublication . CMS collaboration (2122 authors); Hollar, Jonathan; Nayak, Aruna; Bargassa, Pedrame; Beirão Da Cruz E Silva, Cristóvão; Faccioli, Pietro; Ferreira Parracho, Pedro Guilherme; Gallinaro, Michele; Lloret Iglesias, Lara; Nguyen, Federico; Rodrigues Antunes, Joao; Seixas, Joao; Varela, Joao; Vischia, Pietro; David Tinoco Mendes, Andre; Silva, Pedro; Musella, Pasquale; Pela, Joao; Leonardo, NunoThis paper presents distributions of topological observables in inclusive three- and four-jet events produced in pp collisions at a centre-of-mass energy of 7 $\,\text {TeV}$ with a data sample collected by the CMS experiment corresponding to a luminosity of 5.1 $\,\text {fb}^{-1}$ . The distributions are corrected for detector effects, and compared with several event generators based on two- and multi-parton matrix elements at leading order. Among the considered calculations, MadGraph interfaced with pythia6 displays the overall best agreement with data.