Percorrer por autor "Trancoso, Pedro Ferreira"
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- Post-market non-controlled study on the clinical safety of a synthetic calcium phosphate ceramic in alveolar bone regeneration : a 6-month prospective studyPublication . Silva, Nuno; Rodrigues, Carlota; Lobito, Angel; Azul, António Mano; Trancoso, Pedro Ferreira; Machado, Vanessa; Botelho, JoãoThis prospective, single-arm post-market study aimed to evaluate the clinical safety and performance of a synthetic calcium phosphate ceramic used in alveolar bone regeneration procedures. Eighty adult patients requiring bone augmentation were treated with β-tricalcium phosphate (β-TCP) under routine clinical indications. Surgical approaches were adapted to defect morphology. Safety outcomes included adverse events (AEs) and device deficiencies (DDs), while performance outcomes focused on two-dimensional radiographic bone assessment. Radiographic bone consolidation was defined as continuous trabecular radiopacity without radiolucent defects or clinical signs of infection. Patients were followed for six months post-surgery, with clinical and radiographic evaluations, as well as assessment of oral health-related quality of life (OHIP-14). All 80 patients (mean age: 47.2 ± 18.9 years; 51% male) completed the immediate postoperative assessment. Eleven DDs (granule loss) were observed postoperatively (13.8%) and no AEs. At six months, 71 patients (88.8%) completed follow-up. Radiographic bone repair was confirmed in all cases clinically observed and with follow-up X-ray (100%). No AEs or DDs reported (AE-free rate: 100%) at this follow-up. The median OHIP-14 score improved significantly at six months (p = 0.037), indicating better self-reported oral health. Given the observational design, absence of a control group, and partial reliance on non-radiographic follow-up, these findings should be interpreted with caution. Within these limitations, the synthetic calcium phosphate ceramic demonstrated a favorable short-term safety profile and apparent bidimensional radiographic signs of clinical performance under real-world conditions, rather than definitive evidence of effectiveness. Further controlled studies incorporating histological and volumetric analyses are warranted to confirm its regenerative potential.
- Salivary biomarkers in burning mouth syndrome : an umbrella review of systematic reviewsPublication . Machete, Mariana Vallera; Bouaita, Anis; Blanco-Carrión, Andrés; López, José López; Carreras-Presas, Carmen Martín; Mascarenhas, Paulo; Evangelista, José Grillo; Trancoso, Pedro Ferreira; Azul, António Mano; Zagalo, CarlosBackground: Burning Mouth Syndrome (BMS) is a chronic orofacial pain condition without objective diagnostic criteria and with a substantial impact on quality of life. This umbrella review aimed to evaluate the available evidence on salivary biomarkers in BMS, identify which biomarkers show the most consistent associations with the condition, and assess the methodological quality of existing systematic reviews and meta-analyses. Methods: A comprehensive search of PubMed, Embase, Web of Science, Scopus, TRIP, and Google Scholar was conducted without language or date restrictions. Systematic reviews and meta-analyses assessing salivary biomarkers in patients with BMS were included. Of the 561 records screened, six reviews met the eligibility criteria. Methodological quality was assessed using the AMSTAR-2 tool. Results: AMSTAR 2 appraisal rated four reviews as moderate confidence and two as low confidence; none was rated high or critically low. The evidence base showed very high overlap among primary studies, indicating that repeated findings across reviews should not be interpreted as fully independent replications. Cortisol showed the most consistent evidence of elevation in BMS. α-amylase and IgA were also frequently elevated, particularly in reviews on stress-related biomarkers. However, their interpretation was limited by methodological heterogeneity, overlap of primary studies and limited disease specificity. Cytokines, sex hormones, opiorphin, trace elements and oxidative stress-related markers showed inconsistent or sparse evidence. Conclusions: Salivary cortisol, α-amylase and IgA may reflect stress-related neuroendocrine, autonomic and mucosal immune dysregulation in BMS. However, current evidence remains methodologically limited and does not support the use of any salivary biomarker as a standalone diagnostic test. Clinical relevance: Saliva-based biomarkers may support mechanistic phenotyping in future research, but standardised protocols, rigorous study designs and improved patient stratification are required before they can inform clinical decision-making.