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Percorrer por autor "Tenreiro, Sandra"

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  • A biophysical perspective on the unexplored mechanisms driving Parkinson’s disease by amphetamine-like stimulants
    Publication . Ferreira, Carla; Couceiro, Joana; Tenreiro, Sandra; Quintas, Alexandre
    2021-11Contributo em revista Acesso aberto Ver mais
  • Neuroprotection or neurotoxicity of illicit drugs on Parkinson’s disease
    Publication . Ferreira, Carla; Almeida, Catarina; Tenreiro, Sandra; Quintas, Alexandre
    Parkinson’s Disease (PD) is currently the most rapid growing neurodegenerative disease and over the past generation, its global burden has more than doubled. The onset of PD can arise due to environmental, sporadic or genetic factors. Nevertheless, most PD cases have an unknown etiology. Chemicals, such as the anthropogenic pollutant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and amphetamine-type stimulants, have been associated with the onset of PD. Conversely, cannabinoids have been associated with the treatment of the symptoms’. PD and medical cannabis is currently under the spotlight, and research to find its benefits on PD is on-going worldwide. However, the described clinical applications and safety of pharmacotherapy with cannabis products are yet to be fully supported by scientific evidence. Furthermore, the novel psychoactive substances are currently a popular alternative to classical drugs of abuse, representing an unknown health hazard for young adults who may develop PD later in their lifetime. This review addresses the neurotoxic and neuroprotective impact of illicit substance consumption in PD, presenting clinical evidence and molecular and cellular mechanisms of this association. This research area is utterly important for contemporary society since illicit drugs’ legalization is under discussion which may have consequences both for the onset of PD and for the treatment of its symptoms.
    2020-06Contributo em revista Acesso aberto Ver mais
  • Rosmarinic acid-eluting contact lenses as a multifunctional therapeutic system for diabetic ocular complications
    Publication . Duarte, Ana Centeno; Toffoletto, Nadia; Pais, Rita Martins; Monte, Zélia Lumack do; Salema-Oom, Madalena; Tenreiro, Sandra; Serro, Ana Paula
    Drug-eluting contact lenses (CLs) offer a promising approach to treat diabetic eye diseases. Compared to conventional treatments such as eye drops, CLs enhance drug bioavailability and residence time on the eye, while addressing patient compliance issues. Additionally, CLs are a safer alternative to ocular injections. In this study, CLs were designed for the sustained release of rosmarinic acid (RA), a natural polyphenol known for its antioxidant, anti-inflammatory, antibacterial and neuroprotective properties, which has been proposed as an alternative therapy for diabetic ocular complications. Acrylic and silicone-based hydrogels were produced and pre-treated with vitamin E. A sustained release of RA for up to 24 h was achieved under hydrodynamic conditions, which is compatible with the use of this hydrogel as daily CLs. Comprehensive characterization confirmed that the hydrogel’s physicochemical properties met commercial CLs standards, while no signs of ocular irritation nor cytotoxicity were observed in vitro. Ex vivo studies demonstrated that the drug could permeate through ocular tissues. The ocular RA distribution after the CL application was estimated in silico. Finally, the neuroprotective effect of RA was evaluated ex vivo in porcine retinal explants, confirming the therapeutic relevance of the designed hydrogels in the treatment of the diabetic eye.
    2026-02Contributo em revista Acesso aberto Ver mais