Percorrer por autor "Sousa, Andreia"
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- Antitumoral and antimicrobial activities of block copolymer micelles containing gold bisdithiolate complexesPublication . Sousa, Andreia; Santos, Joana F.; Silva, Francisco; Sousa, Sílvia A.; Leitão, Jorge H.; Matos, António P.; Pinheiro, Teresa; Silva, Rafaela A. L.; Belo, Dulce; Almeida, Manuel; Marques, Fernanda; Fernandes, CéliaGold(III) bisdithiolate complexes have been reported as potential antimicrobial and antitumoral agents. The complex [Au(cdc)2]− (cdc=cyanodithioimido carbonate) displayed antimicrobial and outstanding antitumor activity against the ovarian cancer cells A2780 and A2780cisR, which are sensitive and resistant to cisplatin, respectively. However, poor water solubility may hamper its clinical use. Block copolymer micelles (BCMs) may solubilize hydrophobic drugs, improving their bioavailability and circulation time in blood. Aiming to provide water solubility, prolonged availability, and enhanced therapeutic indexes, BCMs loaded with [Au(cdc)2]− were synthesized and characterized. The BCM-[Au(cdc)2] micelles were prepared with a loading efficiency of 64.6% and a loading content of 35.3 mg [Au(cdc)2]−/gBCM. A hydrodynamic diameter of 77.31 ± 27.00 nm and a low polydispersity index of 0.18 indicated that the micelles were homogenous and good candidates for drug delivery. Cytotoxic activity studies against A2780/A2780cisR cells showed that BCM-[Au(cdc)2] maintained relevant cytotoxic activity comparable to the cytotoxicity observed for the same concentration of gold complexes. The Au uptake in A2780 cells, determined by PIXE, was ca. 17% higher for BCMs-[Au(cdc)2] compared to [Au(cdc)2]−. The BCMs-[Au(cdc)2] presented antimicrobial activity against S. aureus Newman and C. glabrata CBS138. These results evidenced the potential of BCM-[Au(cdc)2] for drug delivery and its promising anticancer and antimicrobial activities.
- Dor lombar na Escola Superior de Tecnologia da Saúde do Porto: um estudo de prevalênciaPublication . Sousa, Círia; Mesquita, Cristina; Sousa, AndreiaObjective: To determine the prevalence of self-reported back pain in the last four weeks, distinguishing the known cause of pain with nonspecific, individuals in the Escola Superior de Tecnologia da Saúde do Porto (ESTSP) and find correlation with the degree of disability in symptomatic individuals. Methods: 249 Individuals (students, teachers, administrative and teacher’s assistants), 37 males and 212 females, with average of age 29,6 (±11.0) and 25,4 (±9.67) respectively. This was a quantitative observacional, analytical and transversal study. The instruments used were a questionnaire to characterize the sample and variable low back pain (duration, recurrence, intensity-Visual Analogue Scale (VAS)), and the Roland- Morris questionnaire (disability). Statistical analysis was descriptive and inferential statistics, a significance level α = 0.05. Results: The prevalence in ESTSP was 50.2% (n = 125), of which 15.2% (n = 19) with specific cause stated. The prevalence was higher in females (51.9%) in the class [18-30] (51.1%) and administrative (55.0%). The intensity was 3.5 (± 1.82), and the median disability was 2.00 with range [0.00; 15:00]. There was a correlation between pain intensity and recurrence (rho = 0.40), disability and recurrence (rho = 0.30) and pain intensity and disability (rho = 0.55), p = 0.001. Conclusions: The prevalence of back pain in ESTSP was 50%, this knowledge allows us to evaluate their social impact in terms of costs and disability, which could increase the resources for research. The relationship between pain intensity and disability, pain intensity and recurrence and between recurrence and disability allows the perception of absenteeism caused by this condition.
- Validação de conteúdo da Gait Assessment and Intervention Tool: G.A.I.T., adaptada para o contexto portuguêsPublication . Carvalho, Ana; Sousa, Andreia; Marques, Beatriz; Moreno, Joana; Velez, Tiago; Baleia, Isabel; Santos, Hugo