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- Natural antibacterial compounds with potential for incorporation into dental adhesives : a systematic literature reviewPublication . Sousa, Ana Catarina Neves e; Cruz, Joana Vasconcelos e; Mascarenhas, PauloDental adhesives are essential in modern restorative dentistry and are in constant evolution. However, challenges like secondary caries from bacterial infiltration at the adhesive-tooth interface persist. While synthetic antibacterial agents in adhesives show promise, concerns about their safety have increased interest in natural alternatives that offer a biocompatible, sustainable and effective alternative. Therefore, this study aimed to evaluate whether natural antibacterial compounds in dental adhesives can provide effective antimicrobial activity without compromising their integrity. This systematic review followed PRISMA 2020 statement guidelines. Four databases were screened: PubMed, Scopus, EMBASE and Web of Science, without language or publication date restrictions, until July 2024. Inclusion criteria were in vitro studies that added natural antimicrobial substances to dental adhesives and tested their antibacterial efficacy and physicochemical properties. A quality assessment of the selected studies was conducted. Most of the studies reviewed reported significant antibacterial activity while retaining the adhesive’s integrity, which was generally achieved with lower concentrations of the natural agents. While higher concentrations increase antimicrobial effectiveness, they also tend to negatively impact the adhesive’s properties. This review highlights the promising role of natural antibacterial compounds in enhancing the functionality of dental adhesives, while also pointing to the need for continued research to address challenges.