Browsing by Author "Santos, Liliana"
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- Construindo a integridade familiar no fim da vidaPublication . Silva, Ana Raquel; Marques, Filipa Daniela; Santos, Liliana; Sousa, LilianaA integridade familiar constitui um desafio normal no desenvolvimento das pessoas idosas, fortemente influenciado por factores do sistema familiar. Este estudo pretende aprofundar o conhecimento sobre o que contribui para o desenvolvimento do sentimento de integridade familiar em pessoas idosas. A recolha de dados efectuou-se com a aplicação de uma entrevista semi-estruturada (baseada em King & Wynne, 2004), administrada a 8 indivíduos com idade superior a 64 anos (5 mulheres e 3 homens), que vivem em contexto familiar. Os principais resultados sugerem que o sentido de integridade familiar na pessoa idosa é influenciado por: i) redefinição da identidade pessoal sustentada por uma filosofia de vida; ii) existência de proximidade afectiva nas relações; iii) aceitação de conflitos; iv) satisfação com a transmissão de legado; v) continuidade das relações familiares; vi) existência de projectos de vida futuros. A integridade não exclui contrariedades e amarguras, mas envolve-as num significado de paz com a vida. Na intervenção as pessoas idosas devem ser apoiadas no processo de aceitação de si e do outro, pois este é um mecanismo facilitador da integridade familiar.
- Postmortem analyses unveil the poor efficacy of decontamination, anti-inflammatory and immunosuppressive therapies in Paraquat human intoxicationsPublication . Dinis-Oliveira, Ricardo Jorge; de Pinho, Paula Guedes; Santos, Liliana; Teixeira, Helena; Magalhães, Teresa; Santos, Agostinho; de Lourdes Bastos, Maria; Remião, Fernando; Duarte, José Alberto; Carvalho, FélixBackground: Fatalities resulting from paraquat (PQ) self-poisonings represent a major burden of this herbicide. Specific therapeutic approaches have been followed to interrupt its toxic pathway, namely decontamination measures to prevent PQ absorption and to increase its excretion from organism, as well as the administration of anti-inflammatory and immunosuppressive drugs. Until now, none of the postmortem studies resulting from human PQ poisonings have assessed the relationship of these therapeutic measures with PQ toxicokinetics and related histopathological lesions, these being the aims of the present study. Methodology/principal findings: For that purpose, during 2008, we collected human fluids and tissues from five forensic autopsies following fatal PQ poisonings. PQ levels were measured by gas chromatography-ion trap mass spectrometry. Structural inflammatory lesions were evaluated by histological and immunohistochemistry analysis. The samples of cardiac blood, urine, gastric and duodenal wall, liver, lung, kidney, heart and diaphragm, showed quantifiable levels of PQ even at 6 days post-intoxication. Structural analysis showed diffused necrotic areas, intense macrophage activation and leukocyte infiltration in all analyzed tissues. By immunohistochemistry it was possible to observe a strong nuclear factor kappa-B (NF-kappaB) activation and excessive collagen deposition. Conclusions/significance: Considering the observed PQ levels in all analyzed tissues and the expressive inflammatory reaction that ultimately leads to fibrosis, we conclude that the therapeutic protocol usually performed needs to be reviewed, in order to increase the efficacy of PQ elimination from the body as well as to diminish the inflammatory process.