Percorrer por autor "Rocha, V"
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- Analysis of drugs of abuse and contaminants in individuals under drug surveillance programs: A study in hair samples.Publication . Simão, A Y; Tokuyama, P Y; Zampieri, G; Rocha, V; Madruga, C; Isicawa, K; Cidade, L S; Almeida, K R; da Silva, N R; Barroso, Mário; Andraus, M; Gallardo, EIn this study, over 900 hair samples from individuals using drugs of abuse in São Paulo and Rio Grande do Sul, Brazil were analysed for classical drugs and new psychoactive substances (NPS) in hair samples. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods were developed for the detection of some drugs (25B-NBOMe, 25C-NBOMe, 25E-NBOH, 2C-C, 2C-I, 3,4-MDPHP, 3-MeO-PCP, 5F-MDMB-PINACA, 5-MeO-DMT, cannabidiol, ethylone, JWH 073, ketamine, mephedrone and UR-144) and drug adulterants (levamisole, phenacetin, strychnine); other substances including cocaine, amphetamines, benzodiazepines, opioids, cannabinoids were also analysed. The methods demonstrated good selectivity, linearity with lower limits of quantification ranging from 0.02 to 0.26 ng/mg, as well as precision and accuracy meeting ISO/IEC 17025 criteria. A total of 29.8 % samples were positive for at least one drug. Cocaine and its metabolites were the most frequently detected, with benzoylecgonine (111 cases), cocaine (88 cases), and cocaethylene (37 cases), highlighting prevalent cocaine use. Cannabinoids were also common, with THC (57 cases) and CBN (48 cases) detected. The presence of adulterants such as phenacetin (76 cases), levamisole (14 cases), and strychnine (3 cases) were also identified. Additionally, 5F-MDMB-PINACA was also detected (5 cases), along with ketamine (9 cases). Findings also highlighted a prevalence of poly-drug consumption, where THC was frequently detected with cocaine (20 cases) and benzoylecgonine (26 cases). CBN also showed notable associations with cocaine (16 cases) and benzoylecgonine (22 cases). These findings provide important insights into the evolving drug landscape in Brazil and highlight the effectiveness of hair analysis as a tool for monitoring drug use.
- Prevalence of secondhand smoke exposure in asthmatic children at home and in the car: A cross-sectional studyPublication . Antunes, H; Precioso, J; Araújo, AC; Machado, JC; Samorinha, C; Rocha, V; Gaspar, Â; Becoña, E; Belo-Ravara, S; Vitória, P; Rosas, M; Fernandez, EOBJECTIVE: To compare secondhand smoke exposure (SHSe) prevalence at home and inside the car between asthmatic and non-asthmatic Portuguese children. MATERIALS AND METHODS: This is a cross-sectional study that assessed children's SHSe in a representative sample of nine Portuguese cities. A validated self-reported questionnaire was administered to a random sample of 4th grade students during the school year of 2010/2011. The asthma prevalence was defined by the answers to three questions regarding asthma symptoms, medication and inhaler use. We performed chi-square tests and analysed frequencies, contingency tables, confidence intervals, and odd-ratios. RESULTS: The self-reported questionnaire was administered to 3187 students. Asthma prevalence was 14.8% (472 students). Results showed that 32.3% of non-asthmatic children and 32.4% of asthmatic children were exposed to secondhand smoke as at least one of their household members smoked at home. The prevalence of parental smoking, smoking among fathers and smoking among mothers at home was also similar in both groups (asthmatic and non-asthmatic children). SHSe inside the car was 18.6% among non-asthmatic children and 17.9% among asthmatic children. CONCLUSIONS: Asthmatic and non-asthmatic children were equally exposed to secondhand smoke, because no significant differences were found between the two groups concerning the prevalence of SHSe at home and inside the car. These findings highlight the need to include SHSe brief advice in paediatric asthma management.