Browsing by Author "Pinto, Joana T."
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- Effect of different excipients and processing conditions on casein micellar formulation for childrenPublication . Brachkova, Mariya; Pinto, Joana T.; Fernandes, Ana I.; Pinto, João F."Purpose: Investigation of the potential of casein micellar formulations as drug vehicles in pediatrics."
- Evaluation of the ability of powdered milk to produce mini-tablets to deliver paracetamol in pediatricsPublication . Pinto, Joana T.; Brachkova, Mariya; Fernandes, Ana I.; Pinto, João F."This work aims to evaluate the usefulness of powdered milk as a vehicle of drugs for direct compression into mini-tablets specifically designed for the pediatric population. A 23 full factorial design was carried out to identify the effect of selected variables and their interactions (paracetamol to milk ratio, fraction of disintegrant and compression force), on selected responses (weight variation, thickness and tensile strength of minitablets and dissolution time of paracetamol) of the mini-tablets. Tablets were manufactured according to a matrix design resulting in eight combinations of four different tableting formulations compacted at two distinct forces. Each batch of tablets was evaluated for thickness (n=6), uniformity of weight (n=20), diametric crushing strength and tensile strength (σ) (n=6) and dissolution testing (n=12). A stepwise multiple linear regression was used to identify and quantify the relationships between each response and the variables studied and their interactions. Results were analyzed by ANOVA to identify the significant variables and variable interactions responsible for the effects observed.
- Evaluation of the ability of powdered milk to produce minitablets containing paracetamol for the paediatric populationPublication . Pinto, Joana T.; Brachkova, Maryia I.; Fernandes, Ana I.; Pinto, João F.The work aims at evaluating the usefulness of powdered milk as a drug matrix for the production of minitablets specifically designed for children. Mixtures made of powdered milk, paracetamol, mannitol, sodium croscarmellose and magnesium stearate (evaluated for flow properties, cohesiveness and caking tendency) were compacted into beams (evaluated for deformation, elasticity and stiffness) and minitablets (evaluated for uniformity of mass, thickness, tensile strength and paracetamol mean dissolution time) and a 23 factorial design performed. The increase on milk fraction in the formulation improved the compressibility of paracetamol and hardness of compacts, reducing weight variation and paracetamol release. A marked decrease on the dissolution time was observed as sodium croscarmellose was added to the milk rich formulations. The increase of the compression force resulted in the production of thinner compacts but had little effect on dissolution time. The production of beams has shown that deformation, bending strength and stiffness increased with both milk and compaction pressure, and decreased with sodium croscarmellose, whereas elasticity decreased when all variables increased. Tensile strength and mean dissolution time described minitablets well, unlike compaction force. The study has proved that powdered milk is suitable for the production of minitablets by direct compression of poor compressible drugs.