Browsing by Author "Pedro de Castro, Andreia Marisa"
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- Exploring Biomarkers for Intestinal Permeability in DogsPublication . Pedro de Castro, Andreia Marisa; Montezinho, LilianaThe intestinal epithelium serves as a protective barrier against the ingress of damaging substances into the bloodstream. Intestinal permeability is crucial for sustaining gastrointestinal function, and disruptions in this barrier are reliably linked with diverse ailments. To assess intestinal permeability and provide insight into the integrity of the barrier, biomarkers such as sugars, proteins and lipids are used. Veterinary medicine also acknowledges the significance of investigating intestinal permeability and biomarkers, as animals can develop gastrointestinal disorders. Reliable biomarkers are essential for monitoring the gastrointestinal health in animals and developing effective prevention measures. This review presents the latest advances in comprehending intestinal permeability in veterinary medicine, whit a specific emphasis on dogs. The article discusses the role of the intestinal mucosa, the significance of preserving gut homeostasis, and the contribution of the gut microbiota and intercellular junctions. It explores various biomarkers, such as Zonulin, Calprotectin, Claudins, and Citrulline, with regards to their relevance in evaluating intestinal permeability. However, there is still a lack of consensus on the dependable biomarkers for clinical use. This review highlights the requirement for additional research and comprehension of intestinal permeability to improve diagnostic and therapeutic approaches. From a clinical perspective, it is essential to investigate the role of intestinal permeability in the onset and progression of various pathologies thoroughly. Therefore, obtaining a thorough comprehension of the factors and mechanisms affecting gut permeability can offer fresh perspectives for managing these inflammatory processes and illnesses.