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Percorrer por autor "Martins, L"

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  • The incidence of cancer and potential role of sirolimus immunosuppression conversion on mortality among a single-center renal transplantation cohort of 1,816 patients
    Publication . Branco, F; Cavadas, V; Osório, L; Carvalho, F; Martins, L; Dias, L; Castro-Henriques, A; Lima, E
    INTRODUCTION: The chronic use of immunosuppressive drugs in renal transplant recipients increases the risk of developing de novo malignancies. Herein we analyze the incidence of de novo tumors and the potential role of sirolimus to improve cancer-specific survival among a cohort at a single center. METHODS: This retrospective analysis of our 1,816 patients allografted between January 1983 and December 2009 sought subjects who developed de novo tumors. Epidemiological and clinical data were examined using Mann-Whitney and Pearson's chi-square or Fisher exact tests for statistical comparisons of continuous and categorical variables, respectively. Kaplan-Meier survival curves were used to determine cancer-specific survival according to type of neoplasia and immunosuppressive regimen, namely, conversion to sirolimus. RESULTS: One hundred patients (5.5%) were diagnosed with a de novo malignancy. The 110 different cancers were diagnosed at a median interval of 73 months after kidney transplantation. The overall cancer-specific survivals at 1 and 5 years after cancer diagnosis were 87.0% and 76.9%, respectively. The 15 patients converted to sirolimus showed no difference in survival. CONCLUSION: The observed frequencies of cancer in our center are consistent with the literature. Among our cohort, sirolimus did not significantly impact survival among subjects who had de novo malignancies.
    2011Artigo científico Acesso aberto Ver mais
  • Trauma Associado às Touradas à Corda nos Açores: Um Estudo Transversal
    Publication . Vieira, B; Taranu, V; Vieira, A; Soares, D; Soares, A; Silva, A; Galvão, D; Bagnari, I; Melo, D; Pimentel, F; Sousa, J; Martins, L; Pinheiro, L; Vargas, M; Reis, Ó; Valente, S; Bettencourt, R; Oliveira, T; Mora, A
    Introduction: The aim of the study was to describe trauma injuries associated with rope bullfights in the Azores, Portugal, regarding the cause of the incident, trauma mechanism, most affected anatomical areas, and injury severity. Methods: Two-year cross-sectional study in the local hospital with prospective data collection. Patients who were consecutively admitted to the local hospital’s emergency department with trauma injuries from the bull’s direct impact or from falls either during the bull’s escape or when handling the rope, were included. Data on general demographics, lesion characteristics, treatments, need for hospitalization and mortality were collected. Results: Fifty-six incidents and 80 trauma injuries were identified. The main cause of trauma was the bull’s direct impact (37; 66.07%) and the mechanism of injury was blunt trauma in all patients (100%; 56). Head and neck injuries (27; 33.75%) were the most common. The median Injury Severity Score at the emergency department admission was 4. Major trauma was noted in five patients (8.92%). Ten patients (17.85%) needed hospitalization with a median hospital stay of seven days. Three of the 10 hospitalized patients (30%) were previously admitted to the intensive care unit. Surgery was performed in six patients (10.71%). Conclusion: The main cause of trauma was the bull’s direct impact, and the mechanism of injury was blunt trauma. The most affected anatomical areas were the head and neck. These findings are a wake-up call to the impact of these events regarding the economic costs they entail, the costs for the health of the local population, the safety measures currently implemented and the availability of the necessary means to treat these patients.
    2024Artigo científico Acesso aberto Ver mais