Percorrer por autor "Jacinto, Fernando"
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- Hepatosplenic T-Cell Lymphoma: A Rare Complication of Monotherapy with Thiopurines in Crohn’s DiseasePublication . Carvão, Joana; Magno Pereira, Vítor; Jacinto, Fernando; Sousa Andrade, Carla; Jasmins, LuísHepatosplenic T-cell lymphoma (HSTCL) is an extremely rare and aggressive form of non-Hodgkin lymphoma associated with poor response to treatment and high mortality. There is an increased incidence among patients with inflammatory bowel disease, especially young male patients under 35 years old and on combination therapy (thiopurine and anti-TNF-α). We describe a case of HSTCL in a young male patient with stenosing ileal Crohn's disease on azathioprine monotherapy for 4.8 years admitted to our hospital with intra- abdominal sepsis. Despite chemotherapy, the patient eventually died 1 month after the diagnosis. Through a literature review, we identified 18 additional cases of HSTCL in Crohn's disease patients that had only been treated with thiopurine monotherapy. The authors intend to highlight the rarity of this diagnosis especially with azathioprine monotherapy and the diagnostic challenge in a case that presented with intra-abdominal sepsis.
- Kikuchi-Fujimoto Syndrome: A Rare Entity to ConsiderPublication . Raposo André, Diogo; Vicente, Filipa; Chaves, Jéssica; Caldeira, Mónica; Jacinto, Fernando; Chaves, António José; Brazão, Maria Da LuzKikuchi-Fujimoto disease (KFD) is a rare, benign, necrotizing lymphadenitis of unknown aetiology with good prognosis. It is characterized by c, cand fever. Surgical excision of the c, histopathological study and immunophenotyping are crucial for diagnosis.