Repository logo

Browsing by Author "Guerra, M"

Now showing 1 - 3 of 3
  • Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study
    Publication . Fevereiro-Martins, M; Santos, AC; Marques-Neves, C; Guimarães, H; Bicho, M; Afonso, C; Ferreira, J; Espírito Santo, R; Teixeira, F; Rosa, R; Carneiro, CV; Ferreira, M; Matos, T; Neiva, L; Pereira, S; Aires, S; Parreira, R; Melnik, Z; Faria, J; Teixeira, J; Barros, P; Almeida, J; Malheiro, B; Rodrigues, PC; Albuquerque, L; Freitas, A; Barros, P; Kotchekova, N; Freitas, R; Silveira, AC; Ferreira, A; Morais, B; Teixeira, S; Mota, M; Guerra, M; Coimbra, L; Gigante, J; Ferreira, M; Lapa, P; Monteiro, M; Alfaiate, M; Rodrigues, T; Pina, T; Rosário, M; Silva, R; Breda, J; Bazenga, F; Pinto, JA
    Purpose: To evaluate complete blood count (CBC) parameters in the first week of life as predictive biomarkers for the development of retinopathy of prematurity (ROP). Methods: Multicenter, prospective, observational study of a cohort of preterm infants born with gestational age (GA) < 32 weeks or birth weight < 1500 g in eight Portuguese neonatal intensive care units. All demographic, clinical, and laboratory data from the first week of life were collected. Univariate logistic regression was used to assess risk factors for ROP and then multivariate regression was performed. Results: A total of 455 infants were included in the study. The median GA was 29.6 weeks, and the median birth weight was 1295 g. One hundred and seventy-two infants (37.8%) developed ROP. Median values of erythrocytes (p < 0.001), hemoglobin (p < 0.001), hematocrit (p < 0.001), mean corpuscular hemoglobin concentration (p < 0.001), lymphocytes (p = 0.035), and platelets (p = 0.003) of the group of infants diagnosed with ROP any stage were lower than those without ROP. Mean corpuscular volume (MCV) (p = 0.044), red blood cell distribution width (RDW) (p < 0.001), erythroblasts (p < 0.001), neutrophils (p = 0.030), neutrophils-lymphocytes ratio (p = 0.028), and basophils (p = 0.003) were higher in the ROP group. Higher values of MCV, erythroblasts, and basophils remained significantly associated with ROP after multivariate regression. Conclusion: In our cohort, the increase in erythroblasts, MCV, and basophils in the first week of life was significantly and independently associated with the development of ROP. These CBC parameters may be early predictive biomarkers for ROP.
    2023Journal article Open access Show more
  • Estilos de coping em crianças com doença crónica
    Publication . Lima, Ligia; Lemos, M.S.; Guerra, M
    No domínio da Psicologia da Saúde Infantil o estudo dos processos de confronto tem sido bastante explorado embora grande parte da investigação se centre na avaliação das estratégias de coping e não nos padrões ou estilos de confronto. Os estilos de coping são padrões relativamente estáveis de estratégias que a criança utiliza para lidar com os seus problemas, nomeadamente aqueles que se relacionam com a doença. Os estilos são entendidos como uma variável relativamente estável, próxima do que normalmente se denomina de traço. Este estudo, que se insere num projecto mais alargado sobre a adaptação psicológica de crianças com doença crónica, teve como objectivo estudar os estilos de coping relacionados com a situação de doença, numa amostra de crianças com patologia crónica e em idade escolar. Participaram 87 crianças com idades compreendidas entre os 8 e os 12 anos e com o diagnóstico clínico de asma brônquica. Para avaliação dos estilos de coping foi utilizada a versão portuguesa do “Coping Health Inventory for Children” (Lima et al., 2009). Os resultados demonstraram que os estilos ou padrões de confronto mais frequentes na amostra são aqueles que os autores denominam de adaptativos ou positivos, ou seja, o “Desenvolve Competência e Optimismo” (M=3,93; SD=0,73), “Adere ao tratamento” (M=3,98; SD=0,49;) e “ Procura Apoio” (M=2,72; SD=0,59). Estes resultados vão de encontro aos estudos nesta área que evidenciam que a maioria das crianças com doença crónica consegue adaptar-se de forma positiva à sua condição de doença (Barros, 2003). Outro dado muito interessante surge da associação positiva e estatisticamente signi
    2011Conference object Open access Show more
  • Portuguese recommendations for the use of biological and targeted synthetic diseasemodifying antirheumatic drugs in patients with rheumatoid arthritis – 2020 update
    Publication . Fernandes, Bruno Miguel; Guimarães, F; Almeida, DE; Neto, A; Tavares-Costa, J; Ribeiro, AR; Quintal, Alberto; Pereira, JP; Silva, L; Nóvoa, TS; Faustino, A; Vaz, C; Khmelinskii, N; Samões, B; Dourado, E; Silva, JL; Barcelos, A; Mariz, E; Guerra, M; Santos, MJ; Silvério-António, M; Teixeira, RL; Romão, VC; Santos, H; Santos-Faria, D; Azevedo, S; Rodrigues, A; Dias, JM; Lopes, C; Pinto, P; Couto, M; Miranda, LC; Bernardo, A; Cruz, M; Teixeira, F; Mourão, AF; Neto, A; Teixeira, V; Cordeiro, A; Barreira, S; Inês, LS; Capela, S; Sepriano, A; Canhão, H; Fonseca, JE; Duarte, C; Bernardes, M
    Objective: To update the recommendations for the treatment of rheumatoid arthritis (RA) with biological and targeted synthetic disease-modifying antirheumatic drugs (bDMARDs and tsDMARDs), endorsed by the Portuguese Society of Rheumatology (SPR). Methods: These treatment recommendations were formulated by Portuguese rheumatologists taking into account previous recommendations, new literature evidence and consensus opinion. At a national meeting, in a virtual format, three of the ten previous recommendations were re-addressed and discussed after a more focused literature review. A first draft of the updated recommendations was elaborated by a team of SPR rheumatologists from the SPR rheumatoid arthritis study group, GEAR. The resulting document circulated among all SPR rheumatologists for discussion and input. The level of agreement with each of all the recommendations was anonymously voted online by all SPR rheumatologists. Results: These recommendations cover general aspects such as shared decision, treatment objectives, systematic assessment of disease activity and burden and its registry in Reuma.pt. Consensus was also achieved regarding specific aspects such as initiation of bDMARDs and tsDMARDs, assessment of treatment response, switching and definition of persistent remission. Conclusion: These recommendations may be used for guidance of treatment with bDMARDs and tsDMARDs in patients with RA. As more evidence becomes available and more therapies are licensed, these recommendations will be updated.
    2021-09-23Journal article Open access Show more