Browsing by Author "Brachkova, Mariya"
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- Effect of different excipients and processing conditions on casein micellar formulation for childrenPublication . Brachkova, Mariya; Pinto, Joana T.; Fernandes, Ana I.; Pinto, João F."Purpose: Investigation of the potential of casein micellar formulations as drug vehicles in pediatrics."
- Evaluation of the ability of powdered milk to produce mini-tablets to deliver paracetamol in pediatricsPublication . Pinto, Joana T.; Brachkova, Mariya; Fernandes, Ana I.; Pinto, João F."This work aims to evaluate the usefulness of powdered milk as a vehicle of drugs for direct compression into mini-tablets specifically designed for the pediatric population. A 23 full factorial design was carried out to identify the effect of selected variables and their interactions (paracetamol to milk ratio, fraction of disintegrant and compression force), on selected responses (weight variation, thickness and tensile strength of minitablets and dissolution time of paracetamol) of the mini-tablets. Tablets were manufactured according to a matrix design resulting in eight combinations of four different tableting formulations compacted at two distinct forces. Each batch of tablets was evaluated for thickness (n=6), uniformity of weight (n=20), diametric crushing strength and tensile strength (σ) (n=6) and dissolution testing (n=12). A stepwise multiple linear regression was used to identify and quantify the relationships between each response and the variables studied and their interactions. Results were analyzed by ANOVA to identify the significant variables and variable interactions responsible for the effects observed.