Percorrer por autor "Billot, Marie"
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- Clinical Use of Platelet-Rich Fibrin in Canine and Feline Regenerative MedicinePublication . Billot, Marie; Soares, Carla Sofia AlvesPlatelet-Rich Fibrin (PRF) is defined as a second-generation platelet concentrate, a biomaterial used in Regenerative Medicine. With its simple method of production, it acts as a fibrinous bioscaffold enriched in platelets, leukocytes, growth factors, and cytokines, modulating inflammation, stimulating healing, and promoting angiogenesis. The objectives of this study are to analyze the optimization of the production protocol, characterize its mechanism of action, and evaluate clinical and experimental results in dogs and cats across the specialties of dermatology, ophthalmology, odontology, surgery, and orthopedy. For this purpose, scientific publications from the last ten years were analyzed. Although most studies use autologous PRF, allogenic and xenogenic forms have been explored to overcome some limitations as the blood sampling, especially in cats. Numerous parameters influence the quality of the PRF, such as the speed and duration of centrifugation, and the material of the tubes used for the biomaterial preparation. PRF therapy accelerates healing, reduces infections and inflammation, and limits the use of antimicrobials, thus supporting its integration in the One Health principle. Despite these advantages, some limitations remain, such as inter- and intra-species variability, the need for immediate use, and the low blood volume available in cats.