Browsing by Author "Almeida, Fábio"
Now showing 1 - 2 of 2
Results Per Page
Sort Options
- As Divisões Panzer na 2ª Guerra Mundial nas Campanhas das Ardenas (1940 e 1944-45)Publication . Almeida, FábioO presente trabalho pretende estudar e conhecer a atuação das Divisões Panzer na Segunda Guerra Mundial, nomeadamente na região de Ardenas. As Divisões Panzer foram desenvolvidas para permitir a manobra preconizada pela Blitzkrieg. Tem também como objetivo fazer uma análise comparativa de duas campanhas, a campanha de 1940, que se saldou por um imenso sucesso, e a campanha de 1944-1945, que terminou com uma clara derrota, analisando os condicionalismos do uso dos meios blindados ao longo da guerra. Para a elaboração deste trabalho de investigação, numa primeira fase, são elencados a metodologia e os procedimentos adotados na realização deste estudo. De seguida, é analisado o conceito de Blitzkrieg, uma vez que a sua compreensão é essencial para o entendimento de todo o trabalho. Também é investigado o conceito de Divisão Panzer, uma vez que se trata da organização principal do trabalho e por último, o as Ardenas, o local onde se efetuaram as campanhas. A terceira fase é constituída pela campanha de 1940, é exposta a constituição orgânica das Divisões Panzer e os carros de combate utilizados na campanha; o emprego tático empregue assenta na manobra da Blitzkrieg e o apoio aéreo alemão num papel essencial para obter a supremacia aérea. Também são integradas nesta fase as informações e as transmissões, pois ambas obtiveram um carácter determinante sobre o domínio do inimigo; a logística direcionada para o apoio às Divisões Panzer e a caracterização do inimigo, numa vertente da sua organização, doutrina, carros de combate e aviação. Na quarta fase, constituída pela campanha de 944/45, é analisada a evolução orgânica das Divisões Panzer até 1944 e apresentados os novos carros de combate. Integra também as mudanças no emprego tático, as informações e as transmissões e o fracasso do processo logístico das Divisões Panzer para esta campanha. Consta desta fase a caraterização do inimigo, na vertente orgânica, doutrina, carros de combate, aviação, informações e logística. Assim, conclui-se que as Divisões Panzer obtiveram sucesso na campanha de 1940 devido ao emprego dos seus meios bélicos de acordo com a manobra preconizada de Blitzkrieg. Na campanha de 1944/45, as Divisões Panzer não obtiveram sucesso no mesmo terreno porque se encontravam em declínio logístico e o inimigo tinha mudado. Abstract This work aims to study and understand the actions of the Panzer Divisions in The Second World War, particularly in the Ardennes. The Panzer Divisions were developed to accomplish the Blitzkrieg maneuver. By analyzing the constraints of the use of armored vehicles during the war, this essay will also make a comparative analysis of two campaigns, the 1940 campaign, which resulted in a huge success, and the 1944-45 campaign, which ended with a clear defeat. When doing this research work, our first step is to list the methodology and procedures adopted in this study. Then, the concept of Blitzkrieg is analyzed, since its understanding is essential for the understanding of all the work. We also investigated the concept of the Panzer Division, since it is the main work and lastly, of the Ardennes, the place where the campaigns took place. The third phase consists of the 1940 campaign, explaining the organic structure of the Panzer Divisions and the tanks used in the campaign; the tactics used, based on the Blitzkrieg maneuver, and the German air support with a vital role in achieving air supremacy. The information and transmissions are also included in this phase, since both had decisive importance on dominating the enemy; the logistics directed towards the support of the Panzer Divisions and the characterization of the enemy, relative to the organization, doctrine, Tanks and aviation. The fourth phase consists of the 1944/45 campaign, it analyzes the organic evolution of the Panzer Divisions until 1944 and presents the new tanks. It also includes the changes in the tactics used, information and transmissions and the failure of the logistics process of Panzer Divisions for this campaign. It is also outlined the characterization of the enemy, relative to the organization, doctrine, tanks, aviation, information and logistics.
- Validation of a Novel, Sensitive, and Specific Urine-Based Test for Recurrence Surveillance of Patients With Non-Muscle-Invasive Bladder Cancer in a Comprehensive Multicenter StudyPublication . Batista, Rui; Vinagre, João; Prazeres, Hugo; Sampaio, Cristina; Peralta, Pedro; Conceição, Paulo; Sismeiro, Amílcar; Leão, Ricardo; Gomes, Andreia; Furriel, Frederico; Oliveira, Carlos; Torres, João Nuno; Eufrásio, Pedro; Azinhais, Paulo; Almeida, Fábio; Gonzalez, Edwin Romero; Bidovanets, Bohdan; Ecke, Thorsten; Stinjs, Pascal; Pascual, Álvaro Serrano; Abdelmalek, Rabehi; Villafruela, Ainara; Beardo-Villar, Pastora; Fidalgo, Nuno; Öztürk, Hakan; Gonzalez-Enguita, Carmen; Monzo, Juan; Lopes, Tomé; Álvarez-Maestro, Mario; Servan, Patricia Parra; De La Cruz, Santiago Moreno Perez; Perez, Mario Pual Sanchez; Máximo, Valdemar; Soares, PaulaBladder cancer (BC), the most frequent malignancy of the urinary system, is ranked the sixth most prevalent cancer worldwide. Of all newly diagnosed patients with BC, 70-75% will present disease confined to the mucosa or submucosa, the non-muscle-invasive BC (NMIBC) subtype. Of those, approximately 70% will recur after transurethral resection (TUR). Due to high rate of recurrence, patients are submitted to an intensive follow-up program maintained throughout many years, or even throughout life, resulting in an expensive follow-up, with cystoscopy being the most cost-effective procedure for NMIBC screening. Currently, the gold standard procedure for detection and follow-up of NMIBC is based on the association of cystoscopy and urine cytology. As cystoscopy is a very invasive approach, over the years, many different noninvasive assays (both based in serum and urine samples) have been developed in order to search genetic and protein alterations related to the development, progression, and recurrence of BC. TERT promoter mutations and FGFR3 hotspot mutations are the most frequent somatic alterations in BC and constitute the most reliable biomarkers for BC. Based on these, we developed an ultra-sensitive, urine-based assay called Uromonitor®, capable of detecting trace amounts of TERT promoter (c.1-124C > T and c.1-146C > T) and FGFR3 (p.R248C and p.S249C) hotspot mutations, in tumor cells exfoliated to urine samples. Cells present in urine were concentrated by the filtration of urine through filters where tumor cells are trapped and stored until analysis, presenting long-term stability. Detection of the alterations was achieved through a custom-made, robust, and highly sensitive multiplex competitive allele-specific discrimination PCR allowing clear interpretation of results. In this study, we validate a test for NMIBC recurrence detection, using for technical validation a total of 331 urine samples and 41 formalin-fixed paraffin-embedded tissues of the primary tumor and recurrence lesions from a large cluster of urology centers. In the clinical validation, we used 185 samples to assess sensitivity/specificity in the detection of NMIBC recurrence vs. cystoscopy/cytology and in a smaller cohort its potential as a primary diagnostic tool for NMIBC. Our results show this test to be highly sensitive (73.5%) and specific (93.2%) in detecting recurrence of BC in patients under surveillance of NMIBC.