Publication
Adipose-Derived Stem Cell Therapy Combined With Platelet-Rich Plasma for the Treatment of Avascular Necrosis of the Talus
| dc.contributor.author | Sousa, R | |
| dc.contributor.author | Babulal, J | |
| dc.contributor.author | Amado, P | |
| dc.date.accessioned | 2025-02-19T21:28:31Z | |
| dc.date.available | 2025-02-19T21:28:31Z | |
| dc.date.issued | 2025 | |
| dc.description.abstract | Avascular necrosis (AVN) is characterized by compromised blood supply to bone tissue, often resulting in significant pain and functional impairment. Conservative treatment options for early-stage AVN of the talus are scarce, with non-weight-bearing protocols and hyperbaric oxygen therapy showing limited efficacy. This report presents a potential novel approach to managing non-traumatic AVN of the talus using a combination of adipose-derived stromal vascular fraction (SVF) and platelet-rich plasma (PRP). A 60-year-old male presented with progressive right ankle pain of a two-year evolution. Magnetic resonance imaging (MRI) revealed stage II AVN of the talus with extensive bone infarctions occupying almost all of its volume but with no collapse. A single injection of SVF and PRP was performed after diagnostic arthroscopy, followed by a tailored rehabilitation protocol. The patient experienced significant pain relief, with no further need for analgesics, and was able to return to non-impact sports. At the 18-month follow-up, functional scores showed significant improvement, and MRI showed stable AVN with no evidence of collapse. This report highlights SVF and PRP as a potential effective conservative option for non-traumatic talar AVN. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Cureus . 2025 Jan 17;17(1):e77578. | pt_PT |
| dc.identifier.doi | 10.7759/cureus.77578 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.26/54479 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.subject | Terapia Baseada em Transplante de Células e Tecidos | pt_PT |
| dc.subject | Osteonecrose | pt_PT |
| dc.subject | Tálus | pt_PT |
| dc.subject | Cell- and Tissue-Based Therapy | pt_PT |
| dc.subject | Osteonecrosis | pt_PT |
| dc.subject | Talus | pt_PT |
| dc.title | Adipose-Derived Stem Cell Therapy Combined With Platelet-Rich Plasma for the Treatment of Avascular Necrosis of the Talus | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.title | Cureus | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |