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CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression

2024-03-28Journal article Open access
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dc.contributor.authorRodrigues, Cristiana
dc.contributor.authorLaranjeira, Paula
dc.contributor.authorPinho, A. C. O.
dc.contributor.authorSilva, Isabel
dc.contributor.authorSilva, Sandra
dc.contributor.authorCoucelo, Margarida
dc.contributor.authorOliveira, Ana Catarina
dc.contributor.authorSimões, Ana Teresa
dc.contributor.authorDamásio, Inês
dc.contributor.authorSilva, Helena Matos
dc.contributor.authorUrbano, Mafalda
dc.contributor.authorSarmento Ribeiro, Ana Bela
dc.contributor.authorGeraldes, Catarina
dc.contributor.authorDomingues, Maria Rosario
dc.contributor.authorAlmeida, Julia
dc.contributor.authorCriado, Ignacio
dc.contributor.authorOrfao, Alberto
dc.contributor.authorPaiva, Artur
dc.date.accessioned2024-04-16T15:02:48Z
dc.date.available2024-04-16T15:02:48Z
dc.date.issued2024-03-28
dc.description.abstractIntroduction: In monoclonal B cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL), the expansion of malignant B cells disrupts the normal homeostasis and interactions between B cells and T cells, leading to immune dysregulation. CD20+ T cells are a subpopulation of T cells that appear to be involved in autoimmune diseases and cancer. Methods: Here, we quantified and phenotypically characterized CD20+ T cells from MBL subjects and CLL patients using flow cytometry and correlated our findings with the B-cell receptor mutational status and other features of the disease. Results and discussion: CD20+ T cells were more represented within the CD8+T cell compartment and they showed a predominant memory Tc1 phenotype. CD20+ T cells were less represented in MBL and CLL patients vs healthy controls, particularly among those with unmutated IGVH gene. The expansion of malignant B cells was accompanied by phenotypic and functional changes in CD20+ T cells, including an increase in follicular helper CD4+ CD20+ T cells and CD20+ Tc1 cells, in addition to the expansion of the TCR Vb 5.1 in CD4+ CD20+T cells in CLL.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3389/fonc.2024.1380648pt_PT
dc.identifier.issn2234-943X
dc.identifier.urihttp://hdl.handle.net/10400.26/50636
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Mediapt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/pt_PT
dc.subjectCD20+ T cellspt_PT
dc.subjectchronic lymphocytic leukemiapt_PT
dc.subjectmonoclonal B lymphocytosispt_PT
dc.subjectimmunoglobulin heavy chain variable regionpt_PT
dc.subjectT cell polarizationpt_PT
dc.subjectleucemia linfocítica crónica de células Bpt_PT
dc.subjectcadeias pesadas de imunoglobulinaspt_PT
dc.titleCD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progressionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleFrontiers in Oncologypt_PT
oaire.citation.volume14pt_PT
person.familyNameLaranjeira
person.familyNameOliveira Pinho
person.familyNameSarmento Ribeiro
person.familyNameDomingues
person.familyNameCriado
person.familyNamePaiva
person.givenNamePaula
person.givenNameAryane Cruz
person.givenNameAna Bela
person.givenNameMaria Rosario
person.givenNameIgnacio
person.givenNameArtur
person.identifierB-3806-2014
person.identifier.ciencia-idE918-65E6-11E6
person.identifier.ciencia-idD310-B6B4-D4F4
person.identifier.ciencia-idCE17-DB2F-257C
person.identifier.ciencia-id4016-0372-148E
person.identifier.ciencia-idE41F-9149-A440
person.identifier.ciencia-id7E14-DBD6-0EC3
person.identifier.orcid0000-0002-1136-6118
person.identifier.orcid0000-0003-2235-2237
person.identifier.orcid0000-0002-3426-6363
person.identifier.orcid0000-0002-4142-4841
person.identifier.orcid0000-0001-5357-3601
person.identifier.orcid0000-0003-4120-343X
person.identifier.orcid0000-0002-6562-5859
person.identifier.ridU-9773-2017
person.identifier.ridK-7444-2014
person.identifier.scopus-author-id8444018600
person.identifier.scopus-author-id7003618393
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication12a549eb-beee-45cc-a9e0-e0fcf9d3184c
relation.isAuthorOfPublication65d0701b-0af7-4202-91c3-4d62b69b3436
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relation.isAuthorOfPublication.latestForDiscovery1223106e-f157-4313-9455-f80cad2b1aa5

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