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The Genetic Structure of Cape Verdean Population Revealed by Y-Chromosome STRs

2025-08Text Open access
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datacite.subject.fosCiências Médicas
dc.contributor.authorCainé, Laura
dc.contributor.authorCosta, Rita
dc.contributor.authorFadoni, Jennifer
dc.contributor.authorAmorim, António
dc.contributor.editorAmorim
dc.date.accessioned2025-08-26T14:01:08Z
dc.date.available2025-08-26T14:01:08Z
dc.date.issued2025-08
dc.description.abstractBackground/Objectives: Y-chromosomal short tandem repeats (Y-STR) are genetic markers widely used in forensic and population genetics. However, despite their importance, many populations remain under-represented in published studies and genetic databases. One such population is the Cape Verdean, which, despite its unique history of admixture between European and sub-Saharan African populations, continues to be under-represented in global Y-STR reference databases. This study aims to characterize the Y-STR haplotype diversity and paternal lineage composition of the Cape Verdean population using a high-resolution STR panel. Methods: A total of 143 unrelated Cape Verdean men were analyzed using a set of 26 Y-STR loci, including rapidly mutating markers. Allele and haplotype frequencies were calculated, along with standard forensic parameters such as gene and haplotype diversity. Paternal lineages were inferred, and genetic relationships with other populations were evaluated using distance-based and graphical methods. Results: A total of 135 haplotypes were detected, with 88.8% being unique, yielding a haplotype diversity of 0.999. The most common haplogroups reflected both West African and European ancestry. Genetic distance analysis positioned the Cape Verdean population between African and European groups, supporting its intermediate and admixed genetic background. Conclusions: This study provides the first high-resolution Y-STR dataset for Cape Verdeans, contributing valuable reference data for forensic casework and population genetic studies. The results highlight the utility of extended Y-STR panels in admixed populations and underscore the need to enhance the representation of admixed populations in international forensic reference databaseseng
dc.description.sponsorshipInstituto Nacional de Medicina Legal e Ciências Forenses
dc.identifier.citationCosta, R., Fadoni, J., Amorim, A., & Cainé, L. (2025). The Genetic Structure of Cape Verdean Population Revealed by Y-Chromosome STRs. Genes, 16(9), 999. https://doi.org/10.3390/genes16090999
dc.identifier.doi10.3390/genes16090999
dc.identifier.issn2073-4425
dc.identifier.urihttp://hdl.handle.net/10400.26/58455
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectPopulation Genetics
dc.subjectHaplotype
dc.subjectY Chromosome
dc.subjectCape Verde
dc.subjectArgus Y28
dc.subjectForensic genetics
dc.titleThe Genetic Structure of Cape Verdean Population Revealed by Y-Chromosome STRseng
dc.typetext
dspace.entity.typePublication
oaire.citation.issue9
oaire.citation.titleGenes
oaire.citation.volume16
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCainé
person.familyNameFadoni
person.familyNameAmorim
person.givenNameLaura
person.givenNameJennifer
person.givenNameAntónio
person.identifierAAR-9087-2020
person.identifier.ciencia-id021A-33DD-869D
person.identifier.ciencia-id7715-6D9A-CB35
person.identifier.orcid0000-0002-6542-4256
person.identifier.orcid0000-0002-7593-1059
person.identifier.orcid0000-0002-7506-4426
person.identifier.ridA-4414-2013
person.identifier.scopus-author-id2311978
person.identifier.scopus-author-id35253426400
relation.isAuthorOfPublication1a1e1ffc-1439-48f2-a4c3-359c66db3ad1
relation.isAuthorOfPublication3b4805b7-1f1b-4fcf-b159-875b8ec89084
relation.isAuthorOfPublication71c1447c-fe17-438b-bba1-256e3abdb87a
relation.isAuthorOfPublication.latestForDiscovery1a1e1ffc-1439-48f2-a4c3-359c66db3ad1

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