Publication
Neural antecedents of self-initiated actions in secondary motor cortex
| dc.contributor.author | Murakami, Masayoshi | |
| dc.contributor.author | Vicente, M Inês | |
| dc.contributor.author | Costa, Gil M | |
| dc.contributor.author | Mainen, Zachary F | |
| dc.date.accessioned | 2018-06-29T15:41:09Z | |
| dc.date.available | 2018-06-29T15:41:09Z | |
| dc.date.issued | 2014-09-28 | |
| dc.description.abstract | The neural origins of spontaneous or self-initiated actions are not well understood and their interpretation is controversial. To address these issues, we used a task in which rats decide when to abort waiting for a delayed tone. We recorded neurons in the secondary motor cortex (M2) and interpreted our findings in light of an integration-to-bound decision model. A first population of M2 neurons ramped to a constant threshold at rates proportional to waiting time, strongly resembling integrator output. A second population, which we propose provide input to the integrator, fired in sequences and showed trial-to-trial rate fluctuations correlated with waiting times. An integration model fit to these data also quantitatively predicted the observed inter-neuronal correlations. Together, these results reinforce the generality of the integration-to-bound model of decision-making. These models identify the initial intention to act as the moment of threshold crossing while explaining how antecedent subthreshold neural activity can influence an action without implying a decision. | pt_PT |
| dc.description.sponsorship | ERC 250334, 5-HT Optogenetic | |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.1038/nn.3826 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.26/23196 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.relation | PREFRONTAL CONTROL OF IMPULSIVE ACTIONS | |
| dc.relation | PROGRAMA GULBENKIAN CHAMPALIMAUD EM NEUROCIÊNCIAS | |
| dc.relation | PGDCNC - PROGRAMA DOUTORAL EM BIOLOGIA EXPRIMENTAL E BIOMEDICINA DO CNC | |
| dc.subject | Decision Making | pt_PT |
| dc.subject | Motor Cortex | pt_PT |
| dc.subject | Photic Stimulation | pt_PT |
| dc.subject | Rats | pt_PT |
| dc.title | Neural antecedents of self-initiated actions in secondary motor cortex | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | PREFRONTAL CONTROL OF IMPULSIVE ACTIONS | |
| oaire.awardTitle | PROGRAMA GULBENKIAN CHAMPALIMAUD EM NEUROCIÊNCIAS | |
| oaire.awardTitle | PGDCNC - PROGRAMA DOUTORAL EM BIOLOGIA EXPRIMENTAL E BIOMEDICINA DO CNC | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/PIDDAC/SFRH%2FBPD%2F46314%2F2008/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F33274%2F2007/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/PIDDAC/SFRH%2FBD%2F32947%2F2006/PT | |
| oaire.citation.endPage | 1582 | pt_PT |
| oaire.citation.issue | 11 | pt_PT |
| oaire.citation.startPage | 1574 | pt_PT |
| oaire.citation.title | Nature Neuroscience | pt_PT |
| oaire.citation.volume | 17 | pt_PT |
| oaire.fundingStream | PIDDAC | |
| oaire.fundingStream | PIDDAC | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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