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Y-STR Databases-Application in Sexual Crimes.

2025-04-25Journal article Open access
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datacite.subject.fosCiências Médicas
dc.contributor.authorCosta, Rita
dc.contributor.authorFadoni, Jennifer
dc.contributor.authorAmorim, António
dc.contributor.authorCainé, Laura
dc.date.accessioned2025-06-20T10:48:27Z
dc.date.available2025-06-20T10:48:27Z
dc.date.issued2025-04-25
dc.description.abstractBackground/objectives: The Y chromosome is a crucial tool in forensic genetics due to its unique characteristics, such as its haploid inheritance and lack of recombination. Y-STRs (short tandem repeats on the Y chromosome) are widely used for identifying male genetic profiles in DNA mixtures, especially in sexual assault cases where high levels of female DNA hinder autosomal analysis. This study evaluates the applicability of Y-STRs in forensic investigations, addressing their limitations and the impact of advanced technologies, such as rapidly mutating Y-STRs (RM Y-STRs). Methods: A comprehensive literature review was conducted to analyze existing knowledge on the application of Y-STRs in sexual crimes. The study also examines the role of population databases, such as YHRD, in estimating haplotype frequencies and enhancing forensic reliability. Results: Y-STR analysis proves essential for male DNA identification in complex mixtures, with RM Y-STRs enhancing discriminatory power. However, limitations persist, particularly in cases involving closely related male lineages. The population database coverage remains insufficient in regions like Cape Verde, affecting forensic reliability. Case studies demonstrate Y-STR effectiveness in solving cold cases and sexual crimes, reinforcing the need for expanded databases and methodological advancements. Conclusions: Y-STRs play a fundamental role in forensic genetics, particularly in sexual assault investigations. Their integration with advanced sequencing technologies and expanded databases is critical for improving forensic accuracy. Ethical considerations regarding genetic data privacy and potential discrimination must be addressed through clear regulations and forensic best practices.eng
dc.description.sponsorshipThe APC was funded by Faculty of Medicine, Porto University, Portugal.
dc.identifier.citationCosta, R., Fadoni, J., Amorim, A., & Cainé, L. (2025). Y-STR Databases-Application in Sexual Crimes. Genes, 16(5), 484
dc.identifier.doi10.3390/genes16050484
dc.identifier.issn2073-4425
dc.identifier.urihttp://hdl.handle.net/10400.26/57989
dc.language.isoen
dc.peerreviewedyes
dc.publisherMDPI
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectY chromosome
dc.subjectY-STR
dc.subjectforensic sciences
dc.subjectgenetic diversity
dc.subjecthaplotypes
dc.subjectmicrosatellites
dc.subjectpopulation genetics
dc.subjectsexual crimes
dc.titleY-STR Databases-Application in Sexual Crimes.
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue5
oaire.citation.titleGenes
oaire.citation.volume16
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameFadoni
person.familyNameAmorim
person.familyNameCainé
person.givenNameJennifer
person.givenNameAntónio
person.givenNameLaura
person.identifierAAR-9087-2020
person.identifier.ciencia-id7715-6D9A-CB35
person.identifier.ciencia-id021A-33DD-869D
person.identifier.orcid0000-0002-7593-1059
person.identifier.orcid0000-0002-7506-4426
person.identifier.orcid0000-0002-6542-4256
person.identifier.ridA-4414-2013
person.identifier.scopus-author-id35253426400
person.identifier.scopus-author-id2311978
relation.isAuthorOfPublication3b4805b7-1f1b-4fcf-b159-875b8ec89084
relation.isAuthorOfPublication71c1447c-fe17-438b-bba1-256e3abdb87a
relation.isAuthorOfPublication1a1e1ffc-1439-48f2-a4c3-359c66db3ad1
relation.isAuthorOfPublication.latestForDiscovery3b4805b7-1f1b-4fcf-b159-875b8ec89084

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