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Watch and wait after neoadjuvant treatment in rectal cancer: comparison of outcomes in patients with and without a complete response at first reassessment in the International Watch & Wait Database (IWWD)

2023Journal article Open access
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dc.contributor.authorTemmink, SJ
dc.contributor.authorPeeters, KC
dc.contributor.authorBahadoer, R
dc.contributor.authorKranenbarg, MK
dc.contributor.authorRoodvoets, AG
dc.contributor.authorMelenhorst, J
dc.contributor.authorBurger, JW
dc.contributor.authorWolthuis, A
dc.contributor.authorRenehan, AG
dc.contributor.authorFigueiredo, NL
dc.contributor.authorPares, Or
dc.contributor.authorMartling, A
dc.contributor.authorPerez, RO
dc.contributor.authorBeets, GL
dc.contributor.authorvan de Velde, CJ
dc.contributor.authorNilsson, PJ
dc.contributor.authorAghili, M
dc.contributor.authorKeshvari, A
dc.contributor.authorNouritaromlou, MK
dc.contributor.authorAhlberg, M
dc.contributor.authorKordnejad, S
dc.contributor.authorAleinikov, A
dc.contributor.authorDulskas, A
dc.contributor.authorAsoğlu, O
dc.contributor.authorTokmak, H
dc.contributor.authorBarroca, RG
dc.contributor.authorCaiado, AF
dc.contributor.authorRosa, IA
dc.contributor.authorBreukink, SO
dc.contributor.authorCoraglio, MF
dc.contributor.authorIseas, S
dc.contributor.authorCreaven, B
dc.contributor.authorWinter, DC
dc.contributor.authorZaborowski, A
dc.contributor.authorCunningham, C
dc.contributor.authorGregory, E
dc.contributor.authorCusters, PA
dc.contributor.authorGeubels, BM
dc.contributor.authorDeBrun, L
dc.contributor.authorD’Hoore, A
dc.contributor.authorDimofte, G
dc.contributor.authorFechner, K
dc.contributor.authorMatzel, K
dc.contributor.authorFernandez, L
dc.contributor.authorHerrando, AI
dc.contributor.authorVieira, P
dc.contributor.authorGaertner, WB
dc.contributor.authorMadoff, RD
dc.contributor.authorGerard, JP
dc.contributor.authorJacquinot, F
dc.contributor.authorSchiappa, R
dc.contributor.authorGollins, S
dc.contributor.authorGonzalez, M
dc.contributor.authorVaccaro, CA
dc.contributor.authorHabr-Gama, A
dc.contributor.authorSão Julião, G
dc.contributor.authorHolman, FA
dc.contributor.authorHompes, R
dc.contributor.authorLameris, W
dc.contributor.authorKetelaers, SH
dc.contributor.authorRutten, HJ
dc.contributor.authorLeitner, K
dc.contributor.authorMazzarisi, C
dc.contributor.authorMalcomson, L
dc.contributor.authorO’Dwyer, ST
dc.contributor.authorSaunders, M
dc.contributor.authorMaroli, A
dc.contributor.authorMitchell, P
dc.contributor.authorMurad-Regadas, S
dc.contributor.authorPairola, A
dc.contributor.authorPedraza, SI
dc.contributor.authorSanchez, LF
dc.contributor.authorPennings, AJ
dc.contributor.authorSpinelli, A
dc.contributor.authorSun, MA
dc.date.accessioned2023-10-29T20:58:00Z
dc.date.available2023-10-29T20:58:00Z
dc.date.issued2023
dc.description.abstractBackground: In rectal cancer, watch and wait for patients with a cCR after neoadjuvant treatment has an established evidence base. However, there is a lack of consensus on the definition and management of a near-cCR. This study aimed to compare outcomes in patients who achieved a cCR at first reassessment versus later reassessment. Methods: This registry study included patients from the International Watch & Wait Database. Patients were categorized as having a cCR at first reassessment or at later reassessment (that is near-cCR at first reassessment) based on MRI and endoscopy. Organ preservation, distant metastasis-free survival, and overall survival rates were calculated. Subgroup analyses were done for near-cCR groups based on the response evaluation according to modality. Results: A total of 1010 patients were identified. At first reassessment, 608 patients had a cCR; 402 had a cCR at later reassessment. Median follow-up was 2.6 years for patients with a cCR at first reassessment and 2.9 years for those with a cCR at later reassessment. The 2-year organ preservation rate was 77.8 (95 per cent c.i. 74.2 to 81.5) and 79.3 (75.1 to 83.7) per cent respectively (P = 0.499). Similarly, no differences were found between groups in distant metastasis-free survival or overall survival rate. Subgroup analyses showed a higher organ preservation rate in the group with a near-cCR categorized exclusively by MRI. Conclusion: Oncological outcomes for patients with a cCR at later reassessment are no worse than those of patients with a cCR at first reassessment.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBr J Surg . 2023 May 16;110(6):676-684.pt_PT
dc.identifier.doi10.1093/bjs/znad051pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/47631
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectNeoplasias Colorrectais/tratamentopt_PT
dc.subjectTerapia Neoadjuvantept_PT
dc.subjectConduta Expectantept_PT
dc.subjectRectal Neoplasms/therapypt_PT
dc.subjectRectal Neoplasms/therapypt_PT
dc.subjectWatchful Waitingpt_PT
dc.titleWatch and wait after neoadjuvant treatment in rectal cancer: comparison of outcomes in patients with and without a complete response at first reassessment in the International Watch & Wait Database (IWWD)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage684pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage676pt_PT
oaire.citation.titleBritish Journal of Surgerypt_PT
oaire.citation.volume110pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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