Publication
A randomized trial of nebulized 3% hypertonic saline with salbutamol in the treatment of acute bronchiolitis in hospitalized infants
| dc.contributor.author | Flores, P | |
| dc.contributor.author | Mendes, AL | |
| dc.contributor.author | Neto, AS | |
| dc.date.accessioned | 2016-07-14T20:55:23Z | |
| dc.date.available | 2016-07-14T20:55:23Z | |
| dc.date.issued | 2016-04 | |
| dc.description.abstract | OBJECTIVE: Acute bronchiolitis is a common disorder of infants that often results in hospitalization. Apart from supportive care, no therapy has been shown to influence the course of the disease, except for a possible effect of nebulized hypertonic saline (HS). To determine whether this does have beneficial effects on length of stay in hospital or on severity scores, we undertook a double-blind, randomized, controlled trial in a pediatric department of a Portuguese hospital. METHODS: Previously healthy infants, younger than 12 months, hospitalized with mild-to-moderate acute viral bronchiolitis were randomized to receive either nebulized 3% (hypertonic, HS) or 0.9% (normal, NS) saline during their entire hospital stay. Primary endpoints were: length of hospital stay and severity scores on each day of hospitalization. Need for supplemental oxygen, further add-on medications and adverse effects were also analyzed. RESULTS: Sixty-eight patients completed the study (HS: 33; NS: 35). The median length of hospital stay did not differ between groups: HS: 5.6 ± 2.3 days; NS: 5.4 ± 2.1 days (P = 0.747). We found no difference between groups in severity scores from day 1 to day 4. There were no differences in need for supplemental oxygen or add-on medications. Patients in HS group had significantly more cough (46% vs. 20%, P = 0.025) and rhinorrhoe (58% vs. 31%, P = 0.30). CONCLUSION: This study does not support the use of nebulized HS over NS in therapy of hospitalized children with mild-to-moderate acute viral bronchiolitis | pt_PT |
| dc.identifier.citation | Pediatr Pulmonol. 2016 Apr;51(4):418-25. | pt_PT |
| dc.identifier.doi | 10.1002/ppul.23306 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.26/14327 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.subject | Bronquiolite Viral | pt_PT |
| dc.subject | Broncodilatadores | pt_PT |
| dc.subject | Nebulizadores e Vaporizadores | pt_PT |
| dc.subject | Solução Salina Hipertónica | pt_PT |
| dc.subject | Lactente | pt_PT |
| dc.subject | Bronchodilator Agents | pt_PT |
| dc.subject | Nebulizers and Vaporizers | pt_PT |
| dc.subject | Saline Solution, Hypertonic | pt_PT |
| dc.subject | Bronchiolitis, Viral | pt_PT |
| dc.subject | Infant | pt_PT |
| dc.title | A randomized trial of nebulized 3% hypertonic saline with salbutamol in the treatment of acute bronchiolitis in hospitalized infants | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 425 | pt_PT |
| oaire.citation.issue | 4 | pt_PT |
| oaire.citation.startPage | 418-25 | pt_PT |
| oaire.citation.volume | 51 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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