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G6PD variants, malaria and sensorineural hearing loss in São Tomé and Príncipe: a case-control study
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Abstract(s)
Background: São Tomé and Príncipe (STP) is a least developed country (LDC) on Sub-Saharan Africa, in which was
detected a high prevalence of sensorineural Hearing Loss (SNHL). HL is a common condition with both genetic and
environmental causes, and it greatly impacts on global health. STP population has leading with additional health
problems over the years, such as anaemia and malaria infection. The present study aims to identify the correlation
between the most prevalent G6PD variants and the high prevalence of HL in STP population. Methods: A sample
of 316 individuals collected during Humanitarian Missions in STP, was retrospectively studied in a case-control
approach to evaluate the role of G6PD gene variants in individual susceptibility to HL and it correlation with other
potential risk factors. Results: The results obtained showed an increased risk for those cases that have reported
malaria infection (OR 1.867, CI 95% [1.107-3.48]) in global population. The same effect of increased risk was found
after stratification for male gender (OR 3.721 CI 95% [1.631-8.489]). Conclusions: Our results did not allow us
to correlate any specific variant of G6PD gene with HL. However, emphasize the hypothetical correlation between
malaria infection and the increased risk for HL.
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Citation
Caroça, C., Campelo, P., Caria, H., Paço, J. & Silva, S. N.(2017). G6PD variants, malaria and sensorineural hearing loss in São Tomé and Príncipe: A case-control study. International Journal of Medical Research &Health Sciences, 6(6), p.p. 8-16.