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Serum lactates and acute kidney injury in patients

2017Journal article Open access
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dc.contributor.authorGonçalves, Miguel
dc.contributor.authorGameiro, Joana
dc.contributor.authorPereira, Marta
dc.contributor.authorRodrigues, Natacha
dc.date.accessioned2019-12-06T12:16:10Z
dc.date.available2019-12-06T12:16:10Z
dc.date.issued2017
dc.description.abstractAbstract:Granting the association of lactates with mortality has been largely ocumented in critically ill patients with sepsis, its association with the development of acute kidney injury (AKI) in this setting is not well established. We aimed to analyze the association of serum lactates at intensive care unit (ICU) admission with the occurrence AKI in a cohort of critically ill septic patients. Materials and methods: This study is retrospective including 457 adult patients with sepsis admitted to the Division of Intensive Medicine of the Centro Hospitalar Lisboa Norte (Lisbon, Portugal) between January 2008 and December 2014. The Kidney Disease Improving Global Outcomes (KDIGO) classification was used to diagnose and classify patients developing AKI within the first week of hospitalization. Logistic regression analysis was employed to determine factors associated with AKI development. Data were expressed as odds ratios (ORs) with 95% confidence intervals (CIs). Statistical significance was defined as a p-value < 0.05. Results: AKI occurred in 87.5% of patients with a maximum KDIGO category (19.5% with stage 1, 22.6% with stage 2 and 45.4% with stage 3). Serum lactates were higher among patients developing AKI as compared with non-AKI patients (mmol/L 29.9 ± 25.7 vs. 18.6 ± 9.3, p = 0.001; unadjusted OR 1.04 (95% CI 1.02–1.07), p = 0.001; adjusted OR 1.03 (95% CI 1.01–1.06), p = 0.024), and they were progressively higher in accordance with AKI severity (stage 1, 24.5 ± 18.7; stage 2, 25.5 ± 16.9; stage 3, 34.6 ± 30.7; p = 0.001). Conclusions: Serum lactates at ICU admission were independently associated with the occurrence of AKI in critically ill patients with sepsis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationhttps://doi.org/10.1080/2331205X.2017.1388209pt_PT
dc.identifier.doi10.1080/2331205X.2017.1388209pt_PT
dc.identifier.issn0717-6287
dc.identifier.urihttp://hdl.handle.net/10400.26/30404
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCogent Medicinept_PT
dc.relation.publisherversionGonçalves et al., Cogent Medicine (2017), 4: 1388209,pt_PT
dc.subjectserum lactatespt_PT
dc.subjectacute renal failurept_PT
dc.subjectobesitypt_PT
dc.subjectMadeira Islandpt_PT
dc.subjectPortugalpt_PT
dc.subjectcritically ill patientspt_PT
dc.subjectsepsispt_PT
dc.titleSerum lactates and acute kidney injury in patientspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage9pt_PT
oaire.citation.startPage1pt_PT
person.familyNameGameiro
person.givenNameJoana
person.identifier.orcid0000-0003-2354-6121
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationfaf0be77-9d50-4544-8283-a4f9feaf3620
relation.isAuthorOfPublication.latestForDiscoveryfaf0be77-9d50-4544-8283-a4f9feaf3620

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