Publication
Bowel cleansing effectiveness and safety of 1L PEG + Asc in the real-world setting: Observational, retrospective, multicenter study of over 13000 patients
| dc.contributor.author | López-Jamar, JM | |
| dc.contributor.author | Gorjão, R | |
| dc.contributor.author | Cotter, J | |
| dc.contributor.author | Lorenzo-Zúñiga García, V | |
| dc.contributor.author | Pantaleón Sánchez, MA | |
| dc.contributor.author | Carral Martínez, D | |
| dc.contributor.author | Sábado, F | |
| dc.contributor.author | Pérez Arellano, E | |
| dc.contributor.author | Gómez Rodríguez, BJ | |
| dc.contributor.author | López Cano, A | |
| dc.contributor.author | Machlab, S | |
| dc.contributor.author | Arieira, C | |
| dc.contributor.author | Akriche, F | |
| dc.contributor.author | Turbí Disla, C | |
| dc.contributor.author | Rodriguez Muñoz, S | |
| dc.date.accessioned | 2023-09-10T20:37:28Z | |
| dc.date.available | 2023-09-10T20:37:28Z | |
| dc.date.issued | 2023 | |
| dc.description.abstract | Background and study aims Effective bowel cleansing is critical for detecting lesions during colonoscopy, highlighting the importance of bowel preparations. 1L polyethylene glycol (PEG) + ascorbate (Asc) is the only recommended 1L PEG product in Europe and the United States. Its efficacy was demonstrated in large-scale controlled trials and confirmed in smaller-scale real-world studies. However, no large-scale real-world data exist. Patients and methods This observational, retrospective, multicenter study, used outpatient follow-up data from medical records from 10 centers in Spain and two in Portugal. Outpatients aged ≥18 years using 1L PEG + Asc as bowel preparation were included. The main outcome measures were overall adequate colon cleansing (Boston Bowel Preparation Scale [BBPS] score ≥6 with BBPS score ≥2 in each segment) and high-quality cleansing of the right colon (BBPS score=3). Results Data from 13169 eligible patients were included. Overall cleansing success was achieved in 89.3% (95%CI 88.7%-89.8%) and high-quality cleansing in the right colon in 49.3% (95%CI 48.4%-50.2%) of patients. For the overnight split-dose and same-day regimens, overall adequate quality cleansing success rate was 94.7% and 86.7% ( P <0.0001) and high-quality cleansing of the right colon rate was 65.4% and 41.4% ( P <0.0001), respectively. Colonoscopy was completed in 97.3% of patients, with non-completion due to poor preparation in only 0.8%; 2.3% of patients experienced at least one adverse event (AE). Conclusions This large-scale, real-world study demonstrates the effectiveness of 1L PEG + Asc in the total and right colon, with a low percentage of patients with AEs in routine clinical practice. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Endosc Int Open . 2023 Aug 16;11(8):E785-E793. | pt_PT |
| dc.identifier.doi | 10.1055/a-2125-0025 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.26/46479 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.subject | Colonoscopia | pt_PT |
| dc.subject | Catárticos | pt_PT |
| dc.subject | Colonoscopy | pt_PT |
| dc.subject | Cathartics | pt_PT |
| dc.title | Bowel cleansing effectiveness and safety of 1L PEG + Asc in the real-world setting: Observational, retrospective, multicenter study of over 13000 patients | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | E793 | pt_PT |
| oaire.citation.issue | 08 | pt_PT |
| oaire.citation.startPage | E785 | pt_PT |
| oaire.citation.title | Endoscopy International Open | pt_PT |
| oaire.citation.volume | 11 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |