Inhibition of HIV cell-to-cell fusion by antiretroviral drugs and neutralizing antibodies

Diniz, A. R.; Borrego, P.; Bártolo, I.; Taveira, N.

http://hdl.handle.net/10400.26/15091

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"Inhibition of HIV cell entry by antiretroviral drugs and neutralizing antibodies (NAbs) is typically measured in assays where cell-free virions enter reporter cell lines. However, direct Env-mediated cell-to-cell transmission is a major mechanism of HIV infection that also needs to be targeted. In this work we aimed to determine the ability of anti-HIV compounds in clinical or research use to inhibit HIV mediated cell-to-cell fusion (syncytia formation)."