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Bacterial cellulose membranes as drug delivery systems: An in vivo skin compatibility study

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dc.contributor.authorAlmeida, IF
dc.contributor.authorPereira, T
dc.contributor.authorSilva, NH
dc.contributor.authorGomes, FP
dc.contributor.authorSilvestre, AJ
dc.contributor.authorFreire, CS
dc.contributor.authorSousa-Lobo, JM
dc.contributor.authorCosta, PC
dc.date.accessioned2014-03-06T15:58:30Z
dc.date.available2014-03-06T15:58:30Z
dc.date.issued2013
dc.description.abstractBacterial cellulose (BC) is a highly pure form of cellulose, produced in the form of a swollen membrane by several bacteria that demonstrated to be able to modulate the skin release of model drugs. In the present study, the skin irritation potential of BC was evaluated in human subjects. BC membranes with and without glycerin (acting as plasticizer) were tested. No significant differences were observed for transepidermal water loss (TEWL) measurements in comparison with negative control, 2 and 24h after patch removal, which is an indicator of an absence of barrier disruption. Similar results were found for erythema. Clinical scores were zero at both times for all volunteers, with the exception of five volunteers that exhibited weak reactions. BC with glycerin provided a skin moisturizing effect statistically higher than the negative control (p=0.044), which was not observed for BC alone. The good skin tolerance found after a single application under occlusion reinforces the putative interest of BC membranes as supports for drug topical delivery. Besides modifying the mechanical properties, the inclusion of glycerin results in a skin moisturizing effect which could be clinically relevant for the treatment for skin diseases characterized by dryness, such as psoriasis and atopic dermatitis.por
dc.identifier.citationEur J Pharm Biopharm. 2013. pii: S0939-6411(13)00287-7por
dc.identifier.doi10.1016/j.ejpb.2013.08.008
dc.identifier.urihttp://hdl.handle.net/10400.26/5927
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relation2013 - Strategic Project
dc.subjectAdministration, Cutaneouspor
dc.subjectCellulosepor
dc.subjectDrug Delivery Systemspor
dc.subjectSistemas de Administração de Medicamentospor
dc.subjectCelulosepor
dc.subjectAdministração Cutâneapor
dc.titleBacterial cellulose membranes as drug delivery systems: An in vivo skin compatibility studypor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitle2013 - Strategic Project
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FCTM%2FLA0011%2F2013/PT
oaire.fundingStream6820 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isProjectOfPublication10470ba4-89bc-456b-9371-4bea8ad5c178
relation.isProjectOfPublication.latestForDiscovery10470ba4-89bc-456b-9371-4bea8ad5c178

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