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Effect and longevity of botulinum toxin in the treatment of gummy smile: a meta-analysis and meta-regression

2021-10-15Journal article Restricted access
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dc.contributor.authorZengiski, Aline
dc.contributor.authorBasso, Isabela
dc.contributor.authorCavalcante-Leão, Bianca
dc.contributor.authorNeto, José
dc.contributor.authorSantos, Rosane Sampaio
dc.contributor.authorGuariza‑Filho, Odilon
dc.contributor.authorZeigelboim, Bianca
dc.contributor.authorTaveira, Karinna
dc.contributor.authorAraujo, Cristiano
dc.date.accessioned2022-04-12T15:57:57Z
dc.date.available2022-04-12T15:57:57Z
dc.date.issued2021-10-15
dc.description.abstractObjective: The aim of this systematic review is to synthesize the evidence on the effectiveness and longevity of the botulinum toxin in the treatment of individuals with excessive gingival exposure. Methods: The search was adapted to six electronic databases and gray literature. The risk of bias was assessed using the Cochrane Risk of Bias Assessment Tool for Non-Randomized and Randomized Studies of Interventions. Meta-analyses and meta-regression were performed using random effects models. Results: A total of 5247 articles were collected during the final search in the database, resulting in 17 articles included. There was a mean decrease of 3.42 mm [95% CI = −4.50 to −2.34; I2 = 97%] in the level of gingival exposure 2 weeks after the application of botulinum toxin. The application time explained 29.58% of the observed variance (p < 0.001), with a tendency for the effect size to decrease from the second week of application onwards, with values returning close to baseline levels in 24 weeks. Conclusion: Botulinum toxin is an alternative technique considered effective for reducing gummy smile, especially for gummy smiles up to 4 mm, with a longevity of at least 12 weeks, returning close to initial values within 24 weeks after application. Clinical relevance: The knowledge about the longevity and effectiveness of botulinum toxin in the treatment of gummy smile allows for a more adequate clinical planning for these cases, as well as for clinical decisions, as for prognostic factors.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doihttps://link.springer.com/article/10.1007/s00784-021-04223-wpt_PT
dc.identifier.issn1436-3771
dc.identifier.urihttp://hdl.handle.net/10400.26/40215
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.subjectBotulinum toxins type Apt_PT
dc.subjectGummy smilept_PT
dc.subjectLongevitypt_PT
dc.subjectMeta-analysispt_PT
dc.titleEffect and longevity of botulinum toxin in the treatment of gummy smile: a meta-analysis and meta-regressionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage117pt_PT
oaire.citation.issue2022pt_PT
oaire.citation.startPage109pt_PT
oaire.citation.titleClinical Oral Investigationspt_PT
oaire.citation.volume26pt_PT
person.familyNameSampaio Santos
person.givenNameRosane
person.identifier.orcid0000-0001-6400-5706
person.identifier.ridA-1597-2017
person.identifier.scopus-author-id36097057500
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd56a060e-6046-4eb2-960d-f62fbe1beb09
relation.isAuthorOfPublication.latestForDiscoveryd56a060e-6046-4eb2-960d-f62fbe1beb09

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