Publication
Thrombocytopenia induced by clopidogrel: a rare adverse effect
| dc.contributor.author | Cruz, D | |
| dc.contributor.author | Rodrigues dos Santos, J | |
| dc.contributor.author | Távora, C | |
| dc.date.accessioned | 2023-11-08T21:02:36Z | |
| dc.date.available | 2023-11-08T21:02:36Z | |
| dc.date.issued | 2023 | |
| dc.description.abstract | Introduction: Immune thrombocytopenic purpura (ITP) can be induced by several drugs but there are few case reports of ITP induced by clopidogrel. Second-line treatment with thrombopoietin receptor agonists (TPO-RA) presents solid evidence and should be considered in patients in need of elective surgery who are poor responders to steroids. Case description: We report the case of a 79-year-old male who developed severe immune thrombocytopenic purpura after initiating treatment with clopidogrel. Because he needed elective orthopaedic surgery and he did not respond to corticotherapy and immunoglobulin, second-line treatment with romiplostim was initiated with a significant increase in platelet count. Discussion and conclusion: Clopidogrel can induce ITP and this diagnosis should be considered in patients who present with isolated thrombocytopenia. First-line therapy of ITP is not always successful; second-line treatment with TPO-RA has a high response rate and should be considered in patients in need of elective surgery who have failed to respond to first-line therapy. Learning points: Clopidogrel can cause immune thrombocytopenic purpura (ITP); although there are some published cases in literature, it is a rare adverse effect.ITP induced by clopidogrel should be considered in the differential diagnosis of patients experiencing isolated thrombocytopenia.Second-line treatment of ITP with thrombopoietin receptor agonists (TPO-RA) presents solid evidence and should be considered in patients in need of elective surgery who are poor responders to steroids. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Eur J Case Rep Intern Med . 2023 Oct 5;10(11):004 | pt_PT |
| dc.identifier.doi | 10.12890/2023_004045 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.26/47881 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.subject | Thrombocitopenia | pt_PT |
| dc.subject | Clopidogrel | pt_PT |
| dc.subject | Thrombocytopenia | pt_PT |
| dc.title | Thrombocytopenia induced by clopidogrel: a rare adverse effect | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.title | European Journal of Case Reports in Internal Medicine | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |