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Deep brain stimulation fine-tuning in Parkinson’s disease: short pulse width effect on speech

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dc.contributor.authorFabbri, Margherita
dc.contributor.authorNatale, Federico
dc.contributor.authorArtusi, Carlo Alberto
dc.contributor.authorRomagnolo, Alberto
dc.contributor.authorBozzali, Marco
dc.contributor.authorGiulietti, Giovanni
dc.contributor.authorGuimarães, Isabel
dc.contributor.authorRizonni, Mario Georgio
dc.contributor.authorAccornero, Anna
dc.contributor.authorLopiano, Leonardo
dc.contributor.authorZibetti, Maurizio
dc.date.accessioned2022-04-06T13:22:58Z
dc.date.available2022-04-06T13:22:58Z
dc.date.issued2021
dc.description.abstractBackground: subthalamic nucleus deep brain stimulation (STN-DBS) may have a detrimental effect on speech in Parkinson’s disease (PD) patients and new stimulation technologies may help in addressing this issue. Objective: to evaluate the STN-DBS acute effect of 30 μs pulse width (30PW) versus conventional 60 μs PW (60PW) on speech and identify the core features of voice modified by 30PW. Methods: seven STN-DBS treated PD patients participated into a pilot cross-sectional study. Motor and speech performances were tested by means of both automatic analysis and blinded clinical evaluations in four stimulation conditions: 30PW and 60PW both at the usual amplitude and at an amplitude just below the threshold for stimulation-related side effects. Results: at the threshold amplitude, 30PW stimulation improved speech intelligibility for both words (p = 0.02) and sentences (p = 0.04), without worsening motor performance. A lower but not statistically significant voice variability and instability and percentage of stuttering disfluencies was also observed. The beneficial effect of 30PW detected by automatic analysis, was confirmed by patients’ perception. Conclusions: STN-DBS treated patients experiencing low speech intelligibility may benefit from a 30PW stimulation trial at a higher amplitude. Deep characterization of PD speech profiles may help in a better application of recent DBS hardware advances.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doihttps://10.1016/j.parkreldis.2021.05.07pt_PT
dc.identifier.issn1353-8020
dc.identifier.urihttp://hdl.handle.net/10400.26/40135
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectParkinson’s diseasept_PT
dc.subjectDeep brain stimulationpt_PT
dc.subjectShort-pulse widthpt_PT
dc.subjectDysarthriapt_PT
dc.titleDeep brain stimulation fine-tuning in Parkinson’s disease: short pulse width effect on speechpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage134pt_PT
oaire.citation.issue87pt_PT
oaire.citation.startPage130pt_PT
oaire.citation.titleParkinsonism and Related Disorderspt_PT
person.familyNameGuimarães
person.givenNameIsabel
person.identifier548796
person.identifier.ciencia-idF014-BFD6-49C2
person.identifier.orcid0000-0001-8524-8731
person.identifier.scopus-author-id24586862700
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationdc9a77a2-eecf-4d30-88fa-4200275eccf5
relation.isAuthorOfPublication.latestForDiscoverydc9a77a2-eecf-4d30-88fa-4200275eccf5

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