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Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas

2008Journal article Open access
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dc.contributor.authorPinheiro, C
dc.contributor.authorLongatto-Filho, A
dc.contributor.authorScapulatempo, C
dc.contributor.authorMesquita-Rodrigues, A
dc.contributor.authorAlves, VA
dc.contributor.authorSchmitt, F
dc.contributor.authorBaltazar, F
dc.date.accessioned2012-08-31T15:51:31Z
dc.date.available2012-08-31T15:51:31Z
dc.date.issued2008
dc.description.abstractTumour cells are known to be highly glycolytic, thus producing high amounts of lactic acid. Monocarboxylate transporters (MCTs), by promoting the efflux of the accumulating acids, constitute one of the most important mechanisms in the maintenance of tumour intracellular pH. Since data concerning MCT expression in colorectal carcinomas (CRC) are scarce and controversial, the present study aimed to assess the expressions of MCT1, 2, and 4 in a well characterized series of CRC and assess their role in CRC carcinogenesis. CRC samples (126 cases) were analyzed for MCT1, MCT2, and MCT4 immunoexpression and findings correlated with clinico-pathological parameters. Expression of all MCT isoforms in tumour cells was significantly increased when compared to adjacent normal epithelium. Remarkably, there was a significant gain of membrane expression for MCT1 and MCT4 and loss of plasma membrane expression for MCT2 in tumour cells. Plasma membrane expression of MCT1 was directly related to the presence of vascular invasion. This is the larger study on MCT expression in CRC and evaluates for the first time its clinico-pathological significance. The increased expression of these transporters suggests an important role in CRC, which might justify their use, especially MCT1 and MCT4, as targets in CRC drug therapy.por
dc.identifier.citationVirchows Arch. 2008;452(2):139-46.por
dc.identifier.urihttp://hdl.handle.net/10400.26/2526
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSpringerpor
dc.subjectAdenocarcinoma Mucinosopor
dc.subjectNeoplasias Colorrectaispor
dc.subjectTransportadores de Ácidos Monocarboxílicopor
dc.titleIncreased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomaspor
dc.typejournal article
dspace.entity.typePublication
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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