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A diclofenac-β-cyclodextrin conjugate: from design as colonic pro-drug up to in vivo performance
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Design and synthetic study for a diclofenac cyclodextrin conjugate. Attempts to connect diclofenac through a covalent bond to cyclodextrin, full characterization of the product, and demonstration of the potential of such structure to be used for oral uptake and specific colon delivery of free diclofenac. The pharmacological and therapeutic reasons for such approach, market and industrial economic considerations.
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Contexto Educativo
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Licença CC
Sem licença CC