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Reward-related gustatory and psychometric predictors of weight loss following bariatric surgery: a multicenter cohort study

2021Journal article Open access
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dc.contributor.authorRibeiro, Gabriela
dc.contributor.authorCamacho, Marta
dc.contributor.authorFernandes, Ana B
dc.contributor.authorCotovio, Gonçalo
dc.contributor.authorTorres, Sandra
dc.contributor.authorOliveira-Maia, Albino J
dc.date.accessioned2022-07-05T10:54:38Z
dc.date.available2022-07-05T10:54:38Z
dc.date.issued2021
dc.description.abstractBackground Reward sensitivity has been proposed as a potential mediator of outcomes for bariatric surgery. Objectives We aimed to determine whether gustatory and psychometric measures of reward-related feeding are predictors of bariatric-induced weight loss. Methods A multicenter longitudinal cohort study was conducted in patients scheduled for bariatric surgery (surgical group), assessed at baseline and 2 follow-up assessments. Predictions of % weight loss from baseline (%WL) according to baseline gustatory measures, including intensity and pleasantness ratings of sweet and other tastants, and psychometric measures of reward-related feeding behavior, including hedonic hunger scores, were assessed with multivariable linear regression. Exploratory analyses were conducted to test for associations between %WL and changes in gustatory and psychophysical measures, as well as for comparisons with data from patients on the surgery waiting list (control group). Results We included 212 patients, of whom 96 in the surgical group and 50 in the control group were prospectively assessed. The groups were similar at baseline and, as expected, bariatric surgery resulted in higher %WL (BTreatment-Time = 2.4; 95% CI: 2.1–2.8; P < 0.0001). While variation in gustatory measures did not differ between groups, in the surgery group baseline sweet intensity predicted %WL at the primary endpoint (11 to 18 months postoperatively; β = 0.2; B = 0.2, 95% CI: 0.02 to 0.3; P = 0.02), as did hedonic hunger scores (β = −0.2; B = −2.0, 95% CI: −3.8 to −0.3; P = 0.02). Furthermore, at this endpoint, postsurgical reduction of sweet taste intensity and acceptance of sweet foods were associated with %WL (β = −0.3; B = −3.5, 95% CI: −5.8 to −1.3; P = 0.003, and β = −0.2; B = −4.7, 95% CI: −8.5 to −0.8; P = 0.02, respectively). The use of sweet intensity as a predictor of weight change was confirmed in another bariatric cohort. Conclusions Sweet intensity ratings and hedonic hunger scores predict %WL after surgery. The variability of sweet intensity ratings is also associated with %WL, further suggesting they may reflect physiological processes that are variably modulated by bariatric surgery, influencing clinical outcomes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1093/ajcn/nqaa349pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/41279
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationDopaminergic neurotransmission in dietary learning and obesity
dc.relationModulation of postingestive reward mechanisms by weight loss surgery
dc.relationCenter for Psychology at University of Porto
dc.relationAntidepressant mechanisms of psilocybin: from cortical excitability to brain functional connectivity
dc.relationReinforcement learning from post-ingestive calories: from body to brain in health and disease
dc.subjectfood rewardpt_PT
dc.subjectfeeding behaviorpt_PT
dc.subjectsweet tastept_PT
dc.subjectgustationpt_PT
dc.subjectpsychometrypt_PT
dc.subjectweight losspt_PT
dc.subjectbariatric surgerpt_PT
dc.titleReward-related gustatory and psychometric predictors of weight loss following bariatric surgery: a multicenter cohort studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDopaminergic neurotransmission in dietary learning and obesity
oaire.awardTitleModulation of postingestive reward mechanisms by weight loss surgery
oaire.awardTitleCenter for Psychology at University of Porto
oaire.awardTitleAntidepressant mechanisms of psilocybin: from cortical excitability to brain functional connectivity
oaire.awardTitleReinforcement learning from post-ingestive calories: from body to brain in health and disease
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/HMSP-ICJ%2F0020%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMED-NEU%2F31331%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F128783%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00050%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F130210%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/950357/EU
oaire.citation.endPage761pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage751pt_PT
oaire.citation.titleThe American Journal of Clinical Nutritionpt_PT
oaire.citation.volume113pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamOE
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamH2020
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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