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Control of Neuromuscular Blockade in the Presence of Sensor Faults

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The problem of embedding sensor fault tolerance infeedback control of neuromuscular blockade is considered. Fortackling interruptions of feedback measurements, a structurebased upon Bayesian inference as well as a predictive filter is pro-posed. This algorithm is general and can be applied to differentsituations. Here, it is incorporated in an adaptive automatic systemfor feedback control of neuromuscular blockade using continuousinfusion of muscle relaxants. A significant contribution consistsin the experimental clinical testing of the algorithm in patientsundergoing surgery.

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Lemos, J. M., Magalhães, H., Mendonça, T., Vilela Dionísio, R. (2005). Control of Neuromuscular Blockade in the Presence of Sensor Faults. IEEE Transactions on Biomedical Engineering, 52, (11).

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