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Regulatory T and B cells in asthmatic women: variations from pregnancy to postpartum Treg and Breg: pregnancy to postpartum

2016-06-14Journal article Open access
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dc.contributor.authorMartins, C
dc.contributor.authorLima, J
dc.contributor.authorNunes, G
dc.contributor.authorBorrego, LM
dc.date.accessioned2016-08-11T21:41:03Z
dc.date.available2016-08-11T21:41:03Z
dc.date.issued2016-06-14
dc.description.abstractBACKGROUND: Allergic asthma and rhinitis are common in pregnancy. The immune mechanisms underlying the effects of pregnancy in asthma and vice-versa are not completely understood. OBJECTIVES: This work aimed to study the evolution of regulatory T and B cells in asthmatic pregnant women, from late pregnancy till postpartum. METHODS: Four groups of women were enrolled for this study: third trimester pregnant women, asthmatic (n=24) and healthy (n=43), and non-pregnant women, asthmatic (n=33) and healthy (n=35). Pregnant women were also evaluated postpartum (>6 weeks after delivery). Blood samples were taken from each woman and flow cytometry was used to characterize circulating regulatory T and B cells. Foxp3 expression was assessed within CD4DimCD25Hi regulatory T cells. RESULTS: In asthmatic and healthy pregnant women, regulatory T cells did not oscillate significantly from pregnancy to postpartum, but CD24HiCD38Hi regulatory B cells, decreased in pregnancy, rose significantly postpartum. Foxp3 expression in regulatory T cells was also impaired during pregnancy in asthmatic and healthy pregnant women, recovering postpartum. Nevertheless, asthmatic pregnant women presented higher Foxp3 expression than healthy pregnant women (p=0.007), probably due to the use of control medication. CONCLUSIONS: Women with controlled asthma present variations in regulatory cell subsets during pregnancy and postpartum. The similar pattern observed for Foxp3 expression and CD24HiCD38Hi regulatory B cells during this period corroborates the interaction established between regulatory T and B cells in immune responses. Considering the immunomodulatory potential of these immune mediators, more studies are needed to evaluate their relation with asthma and rhinitis complications in pregnancy.pt_PT
dc.identifier.citationJ Investig Allergol Clin Immunol. 2016 Jun 14. doi: 10.18176/jiaci.0086pt_PT
dc.identifier.doi10.18176/jiaci.0086pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/14443
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectGravidezpt_PT
dc.subjectAsmapt_PT
dc.subjectLinfócitos B Reguladorespt_PT
dc.subjectLinfócitos T Reguladorespt_PT
dc.subjectPeríodo Pós-Partopt_PT
dc.subjectB-Lymphocytes, Regulatorypt_PT
dc.subjectT-Lymphocytes, Regulatorypt_PT
dc.subjectAsthmapt_PT
dc.subjectPregnancypt_PT
dc.subjectPostpartum Periodpt_PT
dc.titleRegulatory T and B cells in asthmatic women: variations from pregnancy to postpartum Treg and Breg: pregnancy to postpartumpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.volume27pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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