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α-Pyrrolidinohexanophenone (α-PHP) and α-Pyrrolidinoisohexanophenone (α-PiHP): A Review

2024-03-22Journal article Open access
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dc.contributor.authorDinis, Pedro
dc.contributor.authorFranco, João
dc.contributor.authorMargalho, Cláudia
dc.date.accessioned2025-01-21T14:35:47Z
dc.date.available2025-01-21T14:35:47Z
dc.date.issued2024-03-22
dc.description.abstractNew Psychoactive Substances are currently a serious and growing problem affecting public health worldwide. By 2022, 1184 of these substances had been identified over a period of 16 years. Within these, α-pyrrolidinohexanophenone (α-PHP) and α-pyrrolidinoisohexanophenone (α-PiHP) have emerged, two synthetic cathinones from the pyrovalerone derivates subgroup that are positional isomers of each other. Alpha-PHP appeared on the Japanese illicit drug market in 2014 and, two years later, α-PiHP was identified for the first time in China. They were placed in schedule II on the list of Psychotropic Substances under International Control in 2020 and in March 2023, respectively. Both cathinones have no therapeutic potential for medical use and therefore are abused for recreational habits, which can lead to fatalities. The most frequent adverse effects reported are cardiac, psychiatric, and neurologic, and fatal intoxications have already been described. In Portugal, their consumption and consequent seizures are more prevalent on the archipelagos, which has been aggravating the health situation. In conclusion, these types of substances are a challenge for forensic toxicology since they are easily synthesized, modified, and placed on the market. Therefore, more studies to develop analytical methods to detect them and more comprehensive legislation should be applied. Thus, this review aimed to address the legislative, physicochemical, toxicological, and analytical aspects of both substances.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDinis, P., Franco, J., & Margalho, C. (2024). α-Pyrrolidinohexanophenone (α-PHP) and α-Pyrrolidinoisohexanophenone (α-PiHP): A Review. Life (Basel, Switzerland), 14(4), 429.pt_PT
dc.identifier.doi10.3390/life14040429pt_PT
dc.identifier.issn2075-1729
dc.identifier.urihttp://hdl.handle.net/10400.26/53939
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://doi.org/10.3390/life14040429pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectα-PHPpt_PT
dc.subjectα-PiHPpt_PT
dc.subjectNPSpt_PT
dc.subjectForensic toxicologypt_PT
dc.titleα-Pyrrolidinohexanophenone (α-PHP) and α-Pyrrolidinoisohexanophenone (α-PiHP): A Reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceBasel, Switzerlandpt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage429pt_PT
oaire.citation.titleLifept_PT
oaire.citation.volume14pt_PT
person.familyNameDias Dinis
person.familyNameFranco
person.familyNameMargalho
person.givenNamePedro Alexandre
person.givenNameJoão
person.givenNameCláudia
person.identifier.ciencia-id1A17-DAC1-3C27
person.identifier.ciencia-idA211-521D-90CA
person.identifier.orcid0009-0007-5443-1411
person.identifier.orcid0000-0002-3268-3841
person.identifier.orcid0000-0003-1661-0367
person.identifier.ridKII-2916-2024
person.identifier.scopus-author-id8655072100
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationc6f87a02-1078-4e3b-9cf1-2e49e195f7de
relation.isAuthorOfPublication045c4125-1313-445f-b05f-b7f204886052
relation.isAuthorOfPublication267f4998-7eea-4d9f-9216-8adcd52fbe1f
relation.isAuthorOfPublication.latestForDiscovery267f4998-7eea-4d9f-9216-8adcd52fbe1f

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