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Curcumins-Loaded ZIF-8 Nanoparticles-Embedded Transdermal Polymeric Patches Increase Apoptosis and Reduce Necrosis in a Dose-Dependent Manner in MCF-7 Cells

2025-12-08Texto Acesso aberto
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datacite.subject.fosCiências Médicas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorKiyak-Kirmaci, Humeysa
dc.contributor.authorAydin, Saliha
dc.contributor.authorYekeler, Humeyra Betul
dc.contributor.authorGuler, Ece
dc.contributor.authorKayaci, Ayse Beyza
dc.contributor.authorGurer, Zeynep
dc.contributor.authorYilmaz-Goler, Ayse Mine
dc.contributor.authorErkmen, Ziya Engin
dc.contributor.authorDuygulu, Ozgur
dc.contributor.authorBostan, Muge Sennaroglu
dc.contributor.authorMartins, Diana
dc.contributor.authorMendes, Fernando
dc.contributor.authorEroglu, Mehmet Sayip
dc.contributor.authorEdirisinghe, Mohan
dc.contributor.authorCam, Muhammet Emin
dc.date.accessioned2026-02-03T10:30:58Z
dc.date.available2026-02-03T10:30:58Z
dc.date.issued2025-12-08
dc.description.abstractCurcumin(Cur)-loaded zeolitic imidazolate framework-8 (ZIF-8) nanoparticles (Cur@ZIF-8 NPs) were produced to increase the anticancer activity of Cur. Cur@ZIF-8 NPs were embedded in polycaprolactone (PCL) fibers as transdermal polymeric patches via a pressured gyration (PG) method to provide controlled release. Cur@ZIF-8 NPs and Cur@ZIF-8 NPs-embedded PCL fibers were characterized for physical, chemical, mechanical, and thermal properties, also biological activities were examined with in vitro tests. Cur@ZIF-8 NPs were produced homogeneously with a size of ∼200 nm and a zeta potential of ∼−19 mV. Cur had better stability inside Cur@ZIF-8 NPs than its powder form. Cur@ZIF-8 NPs were successfully loaded in PCL fibers with a size of∼7 µm, and Cur@ZIF-8 NPs were dispersed amorphously in fibers. Cur was released in a controlled manner, and its efficiency was increased in the acidic microenvironment that is characteristic of cancer. Cur@ZIF-8 NPs have more bioavailability than powdered Cur and can penetrate the cells to deliver their anticancer effects on MCF-7 human breast cancer cells. Cur@ZIF-8 NPs-embedded transdermal polymeric patches promote apoptosis in MCF-7 cells by reducing necrosis, particularly under acidic conditions. This work presents a release system with synergistic anticancer effects, offering a novel approach for Cur’s clinical application in breast cancer through enhanced targeting.eng
dc.identifier.doi10.1002/nano.70048
dc.identifier.eissn2688-4011
dc.identifier.urihttp://hdl.handle.net/10400.26/61398
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley-VCH GmbH
dc.relationThis project was supported by a TUBITAK 2209-A Research Projects Program Grant (2209-A, 2022/-1, No: 1919B012208840, Scientific and Technological Research Council of Turkey-TUBITAK
dc.relation.hasversionhttps://doi.org/10.1002/nano.70048
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectCancer
dc.subjectcurcumin
dc.subjectZIF-8 nanoparticle
dc.titleCurcumins-Loaded ZIF-8 Nanoparticles-Embedded Transdermal Polymeric Patches Increase Apoptosis and Reduce Necrosis in a Dose-Dependent Manner in MCF-7 Cellseng
dc.typetext
dcterms.referencesSupporting Information Additional supporting information can be found online in the Supporting Information section. Supporting file 1: nano70048-sup-0001-SuppMat.docx
dspace.entity.typePublication
oaire.citation.issue12
oaire.citation.titleNano Select
oaire.citation.volume6
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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