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Publication
Sickle Cell Trait, Malaria and Sensorineural Hearing Loss–A Case-Control Study from São Tomé and Príncipe
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Advisor(s)
Abstract(s)
Background: Hearing loss is a problem with higher incidence in South Asia, Asia Pacific and sub-Saharan
Africa. In these countries there is also associated history of anemia and malaria.
Objective: This study aims to identify a putative role of Beta globin mutation - sickle cell trait and HL in São Tomé
and Príncipe population.
Methods: A retrospective case-control study of a convenience sample was collected during Otolaryngologist
Humanitarian Missions in São Tomé and Príncipe. Control group includes individuals with normal hearing in both
ears, and the case group has participants presenting bilateral or unilateral HL. It was evaluated the potential risk
factors and sickle cell trait with HL, as well self-report of malaria infection, consanguinity, familial history of HL. The
HbS gene point mutation (Glu6Val) was determined by PCR-RFLP.
Results: Our results showed a statistical significance between HL - oral language and self-report of HL. Taken
altogether, our data did not reveal association between sickle cell trait and HL. However, a statistical association
between HL and self-report of malaria was found.
Conclusion: No association between sickle cell trait and the high prevalence of HL was found. Self-report of
Malaria was found as a risk factor for the development of HL in São Tomé and Príncipe population. The multifactorial
profile of HL shall not exclude the relevance of other etiologic factors than Malaria to justify the high prevalence of
HL in São Tomé and Príncipe and further investigation must be applied.
Description
Keywords
Perda Auditiva Neurossensorial São Tomé e Príncipe Malaria Traço Falciforme Hemoglobina Falciforme Sickle Cell Trait Hemoglobin, Sickle Hearing Loss, Sensorineural São Tomé and Príncipe
Citation
Otolaryngology. 2016; 6 (6):278-84.