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Is there scientific evidence of the mouthwashes effectiveness in reducing viral load in Covid-19?: a systematic review

2020-09-23Journal article Restricted access
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dc.contributor.authorCavalcante-Leão, Bianca
dc.contributor.authorAraujo, Cristiano
dc.contributor.authorBasso, Isabela
dc.contributor.authorSchroder, Angela
dc.contributor.authorGuariza-Filho, Odilon
dc.contributor.authorRavazzi, Glória
dc.contributor.authorGonçalves, Flavio
dc.contributor.authorZeigelboim, Bianca
dc.contributor.authorSampaio Santos, Rosane
dc.contributor.authorNeto, José Stechman
dc.date.accessioned2022-04-11T15:58:19Z
dc.date.available2022-04-11T15:58:19Z
dc.date.issued2020-09-23
dc.description.abstractBackground: The aim of this research is to verify whether there is evidence in the literature regarding the decrease in viral load present in saliva after using three types of mouthwashes. Material and Methods: Clinical and/or in vitro experimental studies that have used mouthwashes as a form of intervention to reduce the viral load in saliva were included. Combinations of words and appropriate truncations were adapted for each of the seven selected electronic bases including grey literature. Results: The selection of articles was carried out in two phases by two independent reviewers. After removing duplicate articles, 1245 references were maintained, and 2 articles were included in the Systematic Review. Both studies were performed in vitro and tested the virucidal action of the PVP-I solution for mouthwash at two different concentrations, 1% without dilution and 7% with 1:30 dilution, on the SARS-CoV and MERS-CoV viruses. Both showed a viral reduction of ≥ 99.99% with 15 s exposure. Conclusions: Based on the evidence currently available in the literature, PVP-I, at concentrations of 1 and 7%, appears to be the most effective mouthwash for reducing the viral load of COVID-19 present in human saliva. However, the guidelines for dental care refer to the use of hydrogen peroxide but there is insufficient scientific evidence to support this recommendation.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doihttps://doi.org/10.4317/jced.57406pt_PT
dc.identifier.issn1989-5488
dc.identifier.urihttp://hdl.handle.net/10400.26/40201
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMedicina Oral S.Lpt_PT
dc.subjectCovid-19pt_PT
dc.subjectCoronaviruspt_PT
dc.subjectMouthwashpt_PT
dc.subjectChlorhexidinept_PT
dc.subjectHydrogen Peroxidept_PT
dc.subjectPVP-Ipt_PT
dc.titleIs there scientific evidence of the mouthwashes effectiveness in reducing viral load in Covid-19?: a systematic reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPagee189pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPagee179pt_PT
oaire.citation.titleJournal of Clinical and Experimental Dentistrypt_PT
oaire.citation.volume13pt_PT
person.familyNameSampaio Santos
person.givenNameRosane
person.identifier.orcid0000-0001-6400-5706
person.identifier.ridA-1597-2017
person.identifier.scopus-author-id36097057500
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd56a060e-6046-4eb2-960d-f62fbe1beb09
relation.isAuthorOfPublication.latestForDiscoveryd56a060e-6046-4eb2-960d-f62fbe1beb09

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